The ability of cochlear hair cells to convert sound into receptor potentials relies on the mechanoelectrical transducer (MET) channels present in their stereociliary bundles. There is strong evidence implying that transmembrane channel-like protein (TMC) 1 contributes to the pore-forming subunit of the mature MET channel, yet its expression is delayed (~>P5 in apical outer hair cells, OHCs) compared to the onset of mechanotransduction (~P1). Instead, the temporal expression of TMC2 coincides with this onset, indicating that it could be part of the immature MET channel. We investigated MET channel properties from OHCs of homo- and heterozygous Tmc2 knockout mice. In the presence of TMC2, the MET channel blocker dihydrostreptomycin (DHS) had ...
Tip links between adjacent stereocilia are believed to gate mechano-electrical transducer (MET) chan...
Acoustic overexposure and aging can damage auditory synapses in the inner ear by a process known as ...
SummaryHair cells are mechanosensors for the perception of sound, acceleration, and fluid motion. Me...
The ability of cochlear hair cells to convert sound into receptor potentials relies on the mechanoel...
The ability of cochlear hair cells to convert sound into receptor potentials relies on the mechanoel...
SummarySensory transduction in auditory and vestibular hair cells requires expression of transmembra...
AbstractTransmembrane channel-like protein isoform-1 (TMC1) has emerged over the past five years as ...
Mechanoelectrical transducer (MET) currents were recorded from cochlear hair cells in mice with muta...
The transduction of sound into electrical signals depends on mechanically sensitive ion channels in ...
Transmembrane channel-like protein 1 (TMC1) is thought to form the ion-conducting pore of the mechan...
Transmembrane channel like protein 1 (TMC1) is likely to be a pore-forming subunit of the transducti...
SummaryMechanosensitive ion channels at stereocilia tips mediate mechanoelectrical transduction (MET...
Mechanosensitive ion channels at stereocilia tips mediate mechanoelectrical transduction (MET) in in...
The deafness (dn) and Beethoven (Bth) mutant mice are models for profound congenital deafness (DFNB7...
Mechanical stimuli caused by sound waves are detected by hair cells in the cochlea through the openi...
Tip links between adjacent stereocilia are believed to gate mechano-electrical transducer (MET) chan...
Acoustic overexposure and aging can damage auditory synapses in the inner ear by a process known as ...
SummaryHair cells are mechanosensors for the perception of sound, acceleration, and fluid motion. Me...
The ability of cochlear hair cells to convert sound into receptor potentials relies on the mechanoel...
The ability of cochlear hair cells to convert sound into receptor potentials relies on the mechanoel...
SummarySensory transduction in auditory and vestibular hair cells requires expression of transmembra...
AbstractTransmembrane channel-like protein isoform-1 (TMC1) has emerged over the past five years as ...
Mechanoelectrical transducer (MET) currents were recorded from cochlear hair cells in mice with muta...
The transduction of sound into electrical signals depends on mechanically sensitive ion channels in ...
Transmembrane channel-like protein 1 (TMC1) is thought to form the ion-conducting pore of the mechan...
Transmembrane channel like protein 1 (TMC1) is likely to be a pore-forming subunit of the transducti...
SummaryMechanosensitive ion channels at stereocilia tips mediate mechanoelectrical transduction (MET...
Mechanosensitive ion channels at stereocilia tips mediate mechanoelectrical transduction (MET) in in...
The deafness (dn) and Beethoven (Bth) mutant mice are models for profound congenital deafness (DFNB7...
Mechanical stimuli caused by sound waves are detected by hair cells in the cochlea through the openi...
Tip links between adjacent stereocilia are believed to gate mechano-electrical transducer (MET) chan...
Acoustic overexposure and aging can damage auditory synapses in the inner ear by a process known as ...
SummaryHair cells are mechanosensors for the perception of sound, acceleration, and fluid motion. Me...