Add to ORKGGlioblastoma multiforme (GBM) is the most aggressive, infiltrative brain cancer. Tumour recurrence is common and accounts for the poor 5-year survival rates of GBM (<10%). The ability to re-grow the tumour after surgical removal of the tumour bulk has been attributed to cells with stem cell-like phenotypes, termed glioma stem cells (GSCs). Identification of molecular GSC vulnerabilities targetable by therapeutic agents is urgently required. In this context, I examined the potential anti-GSC effect of KHS101, an experimental compound that induces differentiation in neural progenitor cells in vitro and in vivo. Interestingly, in patient-derived GSCs, KHS101 selectively reduced viability. KHS101 cytotoxicity was associated with a vacuolisation...
Glioblastoma multiforme (GBM) is the most common and deadliest brain cancer in adults. Despite consi...
One of the most challenging objective in oncology is the identification of new specific tumor target...
© 2013 Dr. James DimouHigh grade glioma continues to portend a dismal prognosis for patients, despit...
Glioblastoma multiforme (GBM) is the most aggressive, infiltrative brain cancer. Tumour recurrence i...
Glioblastoma multiforme (GBM) is the most malignant form of brain cancer in adults with a very poor ...
Glioblastoma multiforme (GBM) is the most aggressive and common form of primary brain tumor in adult...
Glioblastoma (GBM) is the most common high-grade brain tumor diagnosed in patients who are more than...
Glioblastoma (GBM) is the most malignant primary brain tumor. The current standard approach in GBM i...
Glioblastoma Multiforme (GBM) is the most aggressive and malignant form of brain tumors. The therape...
Despite relevant progress obtained by multimodal treatment, glioblastoma (GBM), the most aggressive ...
Glioblastoma (GB) is one of the most malignant types of central nervous system tumours, classified a...
Glioblastoma (GBM) is known to be the most common and lethal primary malignant brain tumor. Therapie...
Despite relevant progress obtained by multimodal treatment, glioblastoma (GBM), the most aggressive ...
Glioblastoma (GBM) is the most common form of brain tumor characterized by its resistance to convent...
Objectives: Glioblastoma multiforme is the most frequent malignant brain tumor. Patients die within ...
Glioblastoma multiforme (GBM) is the most common and deadliest brain cancer in adults. Despite consi...
One of the most challenging objective in oncology is the identification of new specific tumor target...
© 2013 Dr. James DimouHigh grade glioma continues to portend a dismal prognosis for patients, despit...
Glioblastoma multiforme (GBM) is the most aggressive, infiltrative brain cancer. Tumour recurrence i...
Glioblastoma multiforme (GBM) is the most malignant form of brain cancer in adults with a very poor ...
Glioblastoma multiforme (GBM) is the most aggressive and common form of primary brain tumor in adult...
Glioblastoma (GBM) is the most common high-grade brain tumor diagnosed in patients who are more than...
Glioblastoma (GBM) is the most malignant primary brain tumor. The current standard approach in GBM i...
Glioblastoma Multiforme (GBM) is the most aggressive and malignant form of brain tumors. The therape...
Despite relevant progress obtained by multimodal treatment, glioblastoma (GBM), the most aggressive ...
Glioblastoma (GB) is one of the most malignant types of central nervous system tumours, classified a...
Glioblastoma (GBM) is known to be the most common and lethal primary malignant brain tumor. Therapie...
Despite relevant progress obtained by multimodal treatment, glioblastoma (GBM), the most aggressive ...
Glioblastoma (GBM) is the most common form of brain tumor characterized by its resistance to convent...
Objectives: Glioblastoma multiforme is the most frequent malignant brain tumor. Patients die within ...
Glioblastoma multiforme (GBM) is the most common and deadliest brain cancer in adults. Despite consi...
One of the most challenging objective in oncology is the identification of new specific tumor target...
© 2013 Dr. James DimouHigh grade glioma continues to portend a dismal prognosis for patients, despit...