Plucked human hair as a tissue in which to assess pharmacodynamic end points during drug development studies
- Camidge, D.R.
- Randall, K.R.
- Foster, J.R.
- Sadler, C.J.
- Wright, J.A.
- Soames, A.R.
- Laud, P.J.
- Smith, P.D.
- Hughes, A.M.
DOIAbstract
We have demonstrated the feasibility of detecting and quantifying six cell-cycle-related nuclear markers (Ki67, pRb, p27, phospho-p27 (phosphorylated p27), phospho-pRb (phosphorylated pRb), phospho-HH3 (phosphorylated histone H3)) in plucked human scalp and eyebrow hair. Estimates of the proportion of plucked hairs that are lost or damaged during processing plus the intra- and intersubject variability of each nuclear marker with these techniques are provided to inform sizing decisions for intervention studies with drugs potentially impacting on these markers in the future
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