Surface acoustic waves (SAW) generated in a piezoelectric substrate may be used to manipulate micro-scale droplets of liquid in a digital microfluidic system for lab-on-a-chip applications. The wettability of the surface over which a droplet is driven determines the ease and speed with which the droplet is propelled. This provides the opportunity to achieve fine control of SAW driven droplets simply by patterning of the surface into areas with different levels of wettability. This paper evaluates a number of different materials and surface preparation techniques and assesses their manufacturability and efficacy for this application. Test structures have been designed and developed to help optimise a fabrication process using the biocompatib...