Envenoming by the West African saw-scaled viper, Echis ocellatus resembles that of most vipers, in that it results in local blistering, necrosis and sometimes life-threatening systemic haemorrhage. While effective against systemic envenoming, current antivenoms have little or no effect against local tissue damage. The major mediators of local venom pathology are the zinc-dependant snake venom metalloproteinases (SVMPs). The high degree of structural and functional homology between SVMPs and their mammalian relatives the matrix metalloproteinases (MMPs) suggests that substrate/inhibitor interactions between these subfamilies are likely to be analogous. In this study, four recently developed MMP inhibitors (MMPIs) (Marimastat, AG-3340, CGS-27...
Snake venom metalloproteinases (SVMPs) are predominant in viperid venoms, which provoke hemorrhage a...
Animal-derived antivenoms are the only specific therapies currently available for the treatment of s...
The effectiveness of the chelating agent CaNa2EDTA and the peptidomimetic matrix metalloproteinase i...
Viper envenomation undeniably induces brutal local manifestations such as haemorrhage, oedema and ne...
Viper envenomation undeniably induces brutal local manifestations such as haemorrhage, oedema and ne...
Two metalloproteinases, a 24-kDa P-I EoVMP1 and a 56-kDa P-III EoVMP2, have recently been isolated f...
Russell’s viper bites are potentially fatal from severe bleeding, renal failure and capillary leakag...
Russell’s viper bites are potentially fatal from severe bleeding, renal failure and capillary leakag...
Envenomation by the snake family Viperidae is characterized by hemorrhage, local necrosis, edema, an...
Metalloproteinases are abundant enzymes in crotaline and viperine snake venoms. They are relevant in...
The mortality rate due to snakebite is reduced markedly by the use of anti-venoms, which are the onl...
The majority of snakebite envenomations in Central America are caused by the viperid species <i>Both...
As more data are generated from proteome and transcriptome analysis revealing that metalloproteinase...
Viperbites undeniably cause local manifestations such as hemorrhage and myotoxicity involving substa...
Viperbites undeniably cause local manifestations such as hemorrhage and myotoxicity involving substa...
Snake venom metalloproteinases (SVMPs) are predominant in viperid venoms, which provoke hemorrhage a...
Animal-derived antivenoms are the only specific therapies currently available for the treatment of s...
The effectiveness of the chelating agent CaNa2EDTA and the peptidomimetic matrix metalloproteinase i...
Viper envenomation undeniably induces brutal local manifestations such as haemorrhage, oedema and ne...
Viper envenomation undeniably induces brutal local manifestations such as haemorrhage, oedema and ne...
Two metalloproteinases, a 24-kDa P-I EoVMP1 and a 56-kDa P-III EoVMP2, have recently been isolated f...
Russell’s viper bites are potentially fatal from severe bleeding, renal failure and capillary leakag...
Russell’s viper bites are potentially fatal from severe bleeding, renal failure and capillary leakag...
Envenomation by the snake family Viperidae is characterized by hemorrhage, local necrosis, edema, an...
Metalloproteinases are abundant enzymes in crotaline and viperine snake venoms. They are relevant in...
The mortality rate due to snakebite is reduced markedly by the use of anti-venoms, which are the onl...
The majority of snakebite envenomations in Central America are caused by the viperid species <i>Both...
As more data are generated from proteome and transcriptome analysis revealing that metalloproteinase...
Viperbites undeniably cause local manifestations such as hemorrhage and myotoxicity involving substa...
Viperbites undeniably cause local manifestations such as hemorrhage and myotoxicity involving substa...
Snake venom metalloproteinases (SVMPs) are predominant in viperid venoms, which provoke hemorrhage a...
Animal-derived antivenoms are the only specific therapies currently available for the treatment of s...
The effectiveness of the chelating agent CaNa2EDTA and the peptidomimetic matrix metalloproteinase i...