Artemisinin-acridine hybrids were prepared and evaluated for their in vitro activity against tumour cell lines and a chloroquine sensitive strain of Plasmodium falciparum. They showed a 2-4-fold increase in activity against HL60, MDA-MB-231 and MCF-7 cells in comparison with dihydroartemisinin (DHA) and moderate antimalarial activity. Strong evidence that the compounds induce apoptosis in HL60 cells was obtained by flow cytometry, which indicated accumulation of cells in the G1 phase of the cell cycle. (C) 2009 Elsevier Ltd. All rights reserved
Improvement of quality of life and survival of cancer patients will be greatly enhanced by the devel...
Artemisinin, also known as qinghaosu, is a tetracyclic 1,2,4-trioxane occurring in Artemisia annua. ...
We have tested five distinct classes of established and experimental antimalarial drugs for their an...
Artemisinin–acridine hybrids were prepared and evaluated for their in vitro activity against tumour ...
During this study, 9-aminoacridine and artemisinin–acridine hybrid compounds were synthesized and th...
MSc (Pharmaceutical Chemistry), North-West University, Potchefstroom Campus, 2014Malaria endemic are...
Malaria, one of the three most important life-threatening infectious diseases, is recommended to be ...
A recently developed artemisinin-quinoline hybrid, named 163A, has been shown to display potent acti...
Supplementary data related to this article can be found at http:// dx.doi.org/10.1016/j.ejmech.2014...
Artemisinin–estrogen hybrids were for the first time both synthesized and investigated for their in ...
Artemisinin–estrogen hybrids were for the first time both synthesized and investigated for their in ...
Artemisinin-ferrocene conjugates incorporating a 1,2-disubstituted ferrocene analogous to that embed...
Artemisinin-ferrocene conjugates incorporating a 1,2-disubstituted ferrocene analogous to that embed...
<div><p>We have tested five distinct classes of established and experimental antimalarial drugs for ...
We have tested five distinct classes of established and experimental antimalarial drugs for their an...
Improvement of quality of life and survival of cancer patients will be greatly enhanced by the devel...
Artemisinin, also known as qinghaosu, is a tetracyclic 1,2,4-trioxane occurring in Artemisia annua. ...
We have tested five distinct classes of established and experimental antimalarial drugs for their an...
Artemisinin–acridine hybrids were prepared and evaluated for their in vitro activity against tumour ...
During this study, 9-aminoacridine and artemisinin–acridine hybrid compounds were synthesized and th...
MSc (Pharmaceutical Chemistry), North-West University, Potchefstroom Campus, 2014Malaria endemic are...
Malaria, one of the three most important life-threatening infectious diseases, is recommended to be ...
A recently developed artemisinin-quinoline hybrid, named 163A, has been shown to display potent acti...
Supplementary data related to this article can be found at http:// dx.doi.org/10.1016/j.ejmech.2014...
Artemisinin–estrogen hybrids were for the first time both synthesized and investigated for their in ...
Artemisinin–estrogen hybrids were for the first time both synthesized and investigated for their in ...
Artemisinin-ferrocene conjugates incorporating a 1,2-disubstituted ferrocene analogous to that embed...
Artemisinin-ferrocene conjugates incorporating a 1,2-disubstituted ferrocene analogous to that embed...
<div><p>We have tested five distinct classes of established and experimental antimalarial drugs for ...
We have tested five distinct classes of established and experimental antimalarial drugs for their an...
Improvement of quality of life and survival of cancer patients will be greatly enhanced by the devel...
Artemisinin, also known as qinghaosu, is a tetracyclic 1,2,4-trioxane occurring in Artemisia annua. ...
We have tested five distinct classes of established and experimental antimalarial drugs for their an...