Leucine supplementation combined with resistance exercise improves the plasma lipid profile of dexamethasone-treated rats

Nicastro, Humberto
Luz, Claudia R da
Chaves, Daniela FS
Neves, Willian das
Valente, Kerolyn S
Lancha Junior, Antonio H

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Publication date

January 2012

DOI

10.1186/1476-511X-11-7

Publisher

LONDON

Journal

issn:1476-511X

Abstract

The impact of leucine supplementation and resistance exercise (RE) on plasma lipid profile was evaluated in adult rats treated with dexamethasone, an experimental model of dyslipidemia. Total cholesterol did not differ among groups. Furthermore, leucine supplementation did not promote improvement in the plasma total cholesterol and LDL-c of the animals. However, plasma TG and VLDL-c were significantly decreased and HDL-c increased after 7 days of leucine supplementation combined with RE. In conclusion, leucine supplementation combined with RE, but not isolated, improved the plasma lipid profile of dexamethasone-induced dyslipidemic rats.FAPESP [10/07062-3, 09/52022-2, 2011/04690-6, 10/110852-60