Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei
- Jimenez, Paula Christine
- Wilke, Diego Veras
- Ferreira, Elthon Gois
- Takeara, Renata
- Moraes, Manoel Odorico de
- Silveira, Edilberto Rocha
- Cruz Lotufo, Tito Monteiro da
- Lopes, Norberto Peporine
- Costa-Lotufo, Leticia Veras
DOIAbstract
The present study reports the identification of two new staurosporine derivatives, 2-hydroxy-7-oxostaurosporine (1) and 3-hydroxy-7-oxostaurosporine (2), obtained from mid-polar fractions of an aqueous methanol extract of the tunicate Eudistoma vannamei, endemic to the northeast coast of Brazil. The mixture of 1 and 2 displayed IC50 values in the nM range and was up to 14 times more cytotoxic than staurosporine across a panel of tumor cell lines, as evaluated using the MTT assay.CNPqCAPESInCBFAPES
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