Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features
- Oliveira, Jaqueline Carvalho de
- Scrideli, Carlos Alberto
- Annichini, Maria Sol Brassesco
- Morales, Andressa Gois
- Pezuk, Julia Alejandra
- Queiroz, Rosane Gomes de Paula
- Yunes, Jose Andres
- Brandalise, Silvia Regina
- Tone, Luiz Gonzaga
DOIAbstract
The present study aimed to analyze the expression profile of the microRNAs previously described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a, miR-181b, miR-196b and let-7e, and their association with biological/prognostic features in 128 consecutive samples of childhood acute lymphoblastic leukemia (ALL) by quantitative real-time PCR. A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t(12;21) positive ALL. These findings suggest a potential activity of these microRNAs in pediatric ALL biology. (C) 2011 Elsevier Ltd. All rights reserved.Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Fun...
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