Total synthesis of the proposed azaspiracid-1 structure. Part 1. Construction of the enantiomerically pure C1-C20, C21-C27, and C28-C40 fragments
- Nicolaou, K. C.
- Li, Yiwei
- Uesaka, Noriaki
- Koftis, Theocharis V.
- Vyskocil, Stepan
- Ling, Taotao
- Govindasamy, Mugesh
- Qian, Wenyuan
- Bernal, Federico
- Chen, David Y. -K.
DOIAbstract
As a build-up to the synthesis of the proposed structure of azaspiracid, both enantiomers of fragments 2, 3, and 4 were synthesized stereoselectively. Piv=pivaloyl, PFP=pentafluorophenyl, Teoc=2-(trimethylsilyl)ethoxycarbonyl, TES=triethylsilyl
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