Add to ORKGA number of natural and synthetic analogues of homoazasugars, known in the literature, are promising glycosidase inhibitors. The methodologies used for the synthesis of piperidine homoazasugars are: (i) intramolecular reductive amination, (ii) intermolecular double reductive amination, (iii) amino/amido mercuration, (iv) intramolecular nucleophilic substitution, (v) synthesis from non-carbohydrate building block and aza-heterocycles and (vi) enzyme catalyzed intramolecular reductive amination. Homoazasugars showed higher selectivity and potency in the glycosidase inhibitory activity. In this report, natural occurrence, synthetic methodologies and potential application to glycosidase inhibitory activity of homoazasugars will be reviewed
Several members of a new family of seven-membered azasugars, which can be seen as 1-azasugar ring ho...
This thesis presents the results of studies aimed at the development of general strategies for the s...
Azasugars [e.g., 1-deoxy-aza-xylopyranose (1) Figure 1] are structural analogues of sugars [e.g., α-...
A number of natural and synthetic analogues of homoazasugars, known in the literature, are promising...
A new synthetic strategy has been devised to access a variety of polyhydroxylated piperidines belong...
The syntheses of the polyhydroxylated piperidines deoxygalactonojirimycin 2, homogalactonojirimycins...
Synthesis of novel homoazanucleosides and their peptidyl analogs as hybrid molecules comprised of am...
Synthesis of novel homoazanucleosides and their peptidyl analogs as hybrid molecules comprised of am...
Synthesis of novel homoazanucleosides and their peptidyl analogs as hybrid molecules comprised of am...
An efficient and practical strategy for the synthesis of (3R,4s,5S)-4-(2-hydroxyethyl) piperidine-3,...
Iminosugars are polyhydroxylated alkaloids, and can be generally defined as sugar mimetics in which ...
Azadisaccharides e.g. 399 (Figure 1) are known to be potent selective inhibitors of glycosidases and...
An efficient and practical strategy for the synthesis of (3R,4s,5S)-4-(2-hydroxyethyl) piperidine-3,...
Iminosugars are polyhydroxylated alkaloids, and can be generally defined as sugar mimetics in which ...
Iminosugars are polyhydroxylated alkaloids, and can be generally defined as sugar mimetics in which ...
Several members of a new family of seven-membered azasugars, which can be seen as 1-azasugar ring ho...
This thesis presents the results of studies aimed at the development of general strategies for the s...
Azasugars [e.g., 1-deoxy-aza-xylopyranose (1) Figure 1] are structural analogues of sugars [e.g., α-...
A number of natural and synthetic analogues of homoazasugars, known in the literature, are promising...
A new synthetic strategy has been devised to access a variety of polyhydroxylated piperidines belong...
The syntheses of the polyhydroxylated piperidines deoxygalactonojirimycin 2, homogalactonojirimycins...
Synthesis of novel homoazanucleosides and their peptidyl analogs as hybrid molecules comprised of am...
Synthesis of novel homoazanucleosides and their peptidyl analogs as hybrid molecules comprised of am...
Synthesis of novel homoazanucleosides and their peptidyl analogs as hybrid molecules comprised of am...
An efficient and practical strategy for the synthesis of (3R,4s,5S)-4-(2-hydroxyethyl) piperidine-3,...
Iminosugars are polyhydroxylated alkaloids, and can be generally defined as sugar mimetics in which ...
Azadisaccharides e.g. 399 (Figure 1) are known to be potent selective inhibitors of glycosidases and...
An efficient and practical strategy for the synthesis of (3R,4s,5S)-4-(2-hydroxyethyl) piperidine-3,...
Iminosugars are polyhydroxylated alkaloids, and can be generally defined as sugar mimetics in which ...
Iminosugars are polyhydroxylated alkaloids, and can be generally defined as sugar mimetics in which ...
Several members of a new family of seven-membered azasugars, which can be seen as 1-azasugar ring ho...
This thesis presents the results of studies aimed at the development of general strategies for the s...
Azasugars [e.g., 1-deoxy-aza-xylopyranose (1) Figure 1] are structural analogues of sugars [e.g., α-...