Structure prediction and three-dimensional modeling of disulfide-rich systems are challenging due to the limited number of such folds in the structural databank. We exploit the stereochemical compatibility of substructures in known protein structures to accomodate disulfide bonds in predicting the structures of disulfide-rich polypeptides directly from disulfide connectivity pattern and amino acid sequence in the absence of structural homologs and any other structural information. This knowledge-based approach is illustrated using structure prediction of 40 nonredundant bioactive disulfide-rich polypeptides such as toxins, growth factors, and endothelins available in the structural databank. The polypeptide conformation could be predicted i...
MEDLINE® is the source for the MeSH terms of this document.More than 42,000 3D structures of protein...
Motivation: Disulfide bonds play an important role in protein folding. A precise prediction of disul...
'To whom correspondence should be addressed The bonding states of cysteine play important funct...
Structure prediction and three-dimensional modeling of disulfide-rich systems are challenging due to...
International audienceThe key issue for disulfide bond engineering is to select the most appropriate...
<p>Many cysteine-stabilized antimicrobial peptides from a variety of living organisms could be good ...
Motivation: Disulfide bonds are primary covalent crosslinks between two cysteine residues in protein...
Motivation: Disulfide bonds are primary covalent crosslinks between two cysteine residues in protein...
The significant contribution of naturally occurring disulfide bonds to protein stability has encoura...
The significant contribution of naturally occurring disulfide bonds to protein stability has encoura...
Disulfide bridges strongly constrain the native structure of many proteins and predicting their form...
Many cysteine-stabilized antimicrobial peptides from a variety of living organisms could be good can...
Disulfide bridges have an enormous impact on the structure of a large number of proteins and polypep...
Disulfide bridges have an enormous impact on the structure of a large number of proteins and polypep...
Abstract Background Disulfide bonds are traditionally considered to play only structural roles. In r...
MEDLINE® is the source for the MeSH terms of this document.More than 42,000 3D structures of protein...
Motivation: Disulfide bonds play an important role in protein folding. A precise prediction of disul...
'To whom correspondence should be addressed The bonding states of cysteine play important funct...
Structure prediction and three-dimensional modeling of disulfide-rich systems are challenging due to...
International audienceThe key issue for disulfide bond engineering is to select the most appropriate...
<p>Many cysteine-stabilized antimicrobial peptides from a variety of living organisms could be good ...
Motivation: Disulfide bonds are primary covalent crosslinks between two cysteine residues in protein...
Motivation: Disulfide bonds are primary covalent crosslinks between two cysteine residues in protein...
The significant contribution of naturally occurring disulfide bonds to protein stability has encoura...
The significant contribution of naturally occurring disulfide bonds to protein stability has encoura...
Disulfide bridges strongly constrain the native structure of many proteins and predicting their form...
Many cysteine-stabilized antimicrobial peptides from a variety of living organisms could be good can...
Disulfide bridges have an enormous impact on the structure of a large number of proteins and polypep...
Disulfide bridges have an enormous impact on the structure of a large number of proteins and polypep...
Abstract Background Disulfide bonds are traditionally considered to play only structural roles. In r...
MEDLINE® is the source for the MeSH terms of this document.More than 42,000 3D structures of protein...
Motivation: Disulfide bonds play an important role in protein folding. A precise prediction of disul...
'To whom correspondence should be addressed The bonding states of cysteine play important funct...