Experimental cutaneous lesions in the albino rat

This investigation was undertaken to elucidate the actiology of 'phrynoderma'. Two experiments were conducted, one the study the effect of vitamin A deficiency and the other, to study the part played by fat in the production of cutaneous lesions in rats. It is concluded that deficiency of vitamin A in conjunction with deficiency of essential fatty acids, plays an important role in the production of cutaneous lesions in rats resembling those in 'phrynoderma'. It is suggested that 'phrynoderma' may be due to the combined deficiencies of both these factors. The experimental evidence further points out, that lack of vitamin A plays a larger role in the production of cutaneous lesions resembling 'phrynoderma'