Bioactivity of Flavonoids Isolated from Lychnophora markgravii against Leishmania amazonensis Amastigotes
- SALVADOR, Marcos Jose
- SARTORI, Fabiana Terezinha
- SACILOTTO, Ana Claudia B. C.
- PRAL, Elizabeth M. F.
- ALFIERI, Silvia Celina
- VICHNEWSKI, Walter
Publication date
January 2009
DOI Publisher
VERLAG Z NATURFORSCH ISSN
1865-7125 Journal
issn:0939-5075 Citation count (estimate)
8Abstract
The bioactivity of the flavonoids pinostrobin (1), pinocembrin (2), tectochrysin (3), galangin 3-methyl ether (4), and tiliroside (5) isolated from Lychnophora markgravii aerial parts was investigated in vitro against amastigote stages of Leishmania amazonensis. The compounds were isolated by several chromatographic techniques and their chemical structures were established by ESI-MS and NMR spectroscopic data. The flavonoids 1 and 3 were the most active compounds; they markedly reduced the viability of Leishmania amastigotes.CNPqConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)CAPESFAPESPFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP
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