Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma
- GRAEBIN, Cedric S.
- MADEIRA, Maria de F.
- YOKOYAMA-YASUNAKA, Jenicer K. U.
- MIGUEL, Danilo C.
- ULIANA, Silvia R. B.
- BENITEZ, Diego
- CERECETTO, Hugo
- GONZALEZ, Mercedes
- ROSA, Ricardo Gomes da
- EIFLER-LIMA, Vera Lucia
Publication date
January 2010
DOI Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER Journal
issn:0223-5234Abstract
The synthesis and in vitro activity of R(+)-Limonene derivatives against Leishmania and Trypanosoma cruzi strains are reported. Seven compounds have shown better in vitro activity against Leishmania (V.)braziliensis than the standard drug pentamidine. Additionally, we have identified two promising new anti-T. cruzi limonene derivatives. (C) 2010 Elsevier Masson SAS. All rights reserved.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)CAPES/MECCNPq[MCT/CNPq 02/2006]Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)CNPq[MCT/CNPq 14/2008]Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPES
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