Non-Human Leukocyte Antigen Antibodies Reactive with Endothelial Cells Could Be Involved in Early Loss of Renal Allografts
- RONDA, C.
- BORBA, S. C. P.
- FERREIRA, S. C. P.
- GLOTZ, D.
- IANHEZ, L. E.
- RODRIGUES, H.
- VIGGIANI, C. S.
- NAHAS, W.
- DAVID-NETO, E.
- CASTRO, M. C. R.
- DAISA, S. R. David
- KALIL, J.
- PANAJOTOPOULOS, N.
Publication date
January 2011
DOI Publisher
ELSEVIER SCIENCE INC Journal
issn:0041-1345Abstract
Preformed donor-specific human leukocyte antigen (HLA) antibodies have been associated with allograft dysfunction and failure. However, recipients of HLA-identical kidneys can develop acute humoral rejection, implicating putative pathogenic antibodies that are directed against non-HLA antigens. We investigated the presence of endothelial cell reactive antibodies in 11 patients who experienced early loss of their transplanted kidneys owing to humoral rejection and 1 loss from renal venal thrombosis. We examined the potential efficacy of intravenous immunoglobulin to block the binding of these antibodies, as previously suggested for anti-HLA antibodies
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