Chemokine Receptors Expression on T Cells and Response to HAART Among Chronic HIV-1-Infected Subjects
- BRITO, Adriana
- RIGATO, Paula O.
- ALMEIDA, Alexandre
- FERNANDES, Simone S.
- GONSALEZ, Claudio R.
- FONSECA, Luiz A. M.
- DUARTE, Alberto J. S.
- CASSEB, Jorge
DOIAbstract
Chemokines receptors are used by HIV-1 for entry into CD4(+) T cells. The chemokines are capable of inhibiting HIV replication. This study determined the CCR5 and CXCR4 expression on T cells in HIV-1-infected patients treated with HAART. The successfully treated group ( plasma viral load 400 copies/mL), when compared with the failure group ( plasma viral load >400 copies/mL), had higher median CD4+ T cells count ( 583 and 245 cells/mm(3); respectively, p<0.0001). The failure patients had higher numbers and intensity of CCR5 and CXCR4-expressing T cells. Successfully treated patients were able to normalize the co-receptors expression-over on T cells. The viremic group showed higher CCR5 expression on CD4+ T cells and lower number of cells; C...
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