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S/2017/982 6/20 17-20456 casualties remains a strong indication that violations of the prohibition on launching indiscriminate attacks and of the principles of proportionality and precaution are continuing. Children are particularly affected by the fighting and, in some incidents, have constituted the majority of the casualties. 14. Fighting continued to affect civilian infrastructure, including medical facilities, schools, markets and places of worship. On the basis of information received by the Office of the United Nations High Commissioner for Human Rights (OHCHR), civilian casualties occurred in various governorates (see annex), in possible violation of international humanitarian law. OHCHR has documented alleged incidents perpetrated by many parties to the conflict, including Government forces and their allies, non-State armed opposition groups and Security Council-designated terrorist groups. 15. In addition, the Government of the Syrian Arab Republic provided OHCHR with information on alleged violations. In a note verbale received on 3 November, the Permanent Mission of the Government of the Syrian Arab Republic to the United Nations provided OHCHR with a list of reported casualties and injured civilians between 22 September and 21 October in Damascus, Rif Dimashq, Dar‘a, Suwayda’, Homs, Hama, Tartus, Ladhiqiyah, Idlib, Aleppo, Dayr al-Zawr, Hasakah, Qunaytirah, and Raqqah. A total of 61 civilians, 15 of them children, were reported to have been killed and 238 injured, including 73 children. The casualties were reported to have been the result of mortars and explosive devices. 16. Despite the call made to the Syrian authorities in Human Rights Council resolution 19/22 to cooperate with OHCHR, including through the establishment of a field presence with the mandate to protect and promote human rights, further reporting by the Office remains curtailed by the denial of access for it to the Syrian Arab Republic. 17. The United States Department of Defense publicly confirmed that, in October, the United States-led coalition carried out 495 strikes against ISIL targets in the Governorates of Hasakah, Raqqah and Dayr al-Zawr. Nearly 75 per cent of the strikes (or 371 air strikes) were reported to have been in the vicinity of Raqqah city and 21 per cent in Dayr al-Zawr. In addition, the United States Department of Defense reported that the coalition had conducted airstrikes near Mayadin on 2 and 3 October, near Hajin on 3 October, and near Albu Kamal on 9 October. 18. The Ministry of Defence of the Russian Federation issued a statement on 13 October noting that there had been intensified airstrikes on Dayr al-Zawr Governorate, with Russian aircraft carrying out 383 sorties which hit 993 targets in Dayr al-Zawr Governorate over the previous week. They further noted that three large-scale strikes had been launched using both sea- and air-launched cruise missiles over the month. 19. The United Nations and its health partners received credible reports of four attacks that affected health-care facilities and personnel in October, of which two have been verified. On 6 October, an attack on Shifa‘ primary health care centre in Duma, Rif Dimashq, resulted in damage to the facility building, as well as damage to at least one ambulance. The facility went out of service. On 12 October, the World Health Organization (WHO) received reports of an attack that destroyed the only vaccines cold room in Mayadin district, Dayr al-Zawr Governorate. More than 100,000 doses of measles vaccines and 35,000 doses of polio vaccines were stored in the facility, together with equipment, syringes and stocks for all vaccine-preventable childhood diseases. This is a setback for efforts to control the polio outbreak in the area, with new cases continuing to be reported