Endopap®- versus Pipelle®-sampling in the diagnosis of postmenopausal endometrial disease

Objective: To evaluate the accuracy of Endopap®- and Pipelle®-sampling in the diagnosis of postmenopausal disease. Study Design: Observational study in the setting of a University Hospital. One hundred and six consecutive postmenopausal women presenting with uterine bleeding or endometrial cells on cervical cytology underwent an Endopap® sampling as well as a Pipelle® biopsy. Thereafter, 89 of those women underwent a hysteroscopy and curettage (n = 71) or a hysterectomy (n = 18). The diagnostic accuracy of Pipelle® and Endopap® was assessed against the final diagnosis. Results: Endometrial carcinoma was found in five cases (6%), benign disease in 34 (38%). The sensitivity of Endopap® and Pipelle® for the detection of endometrial disease was 56 and 51%, respectively, with a specificity of 94 and 100%, respectively. The sensitivity for endometrial carcinoma was 80% for Endopap® and 100% for Pipelle®. Conclusion: Our data tend to favor Pipelle® against Endopap® as diagnostic tool in endometrial disease in symptomatic postmenopausal women.Articl