Effects of Early Placement of Transjugular Portosystemic Shunts in Patients With High-Risk Acute Variceal Bleeding: a Meta-analysis of Individual Patient Data
- Nicoara-Farcau O.
- Han G.
- Rudler M.
- Angrisani D.
- Monescillo A.
- Torres F.
- Casanovas G.
- Bosch J.
- Lv Y.
- Thabut D.
- Fan D.
- Hernandez-Gea V.
- Garcia-Pagan J. C.
- Bureau C.
- Abraldes J. G.
- Nevens F.
- Caca K.
- Laleman W.
- Appenrodt B.
- Luca A.
- Vinel J. P.
- Mossner J.
- Di Pascoli M.
- Zipprich A.
- Sauerbruch T.
- Martinez-Lagares F.
- Ruiz-del-Arbol L.
- Sierra A.
- Guevara C.
- Jimenez E.
- Marrero J. M.
- Buceta E.
- Sanchez J.
- Castellot A.
- Penate M.
- Cruz A.
- Pena E.
- Procopet B.
- Giraldez A.
- Amitrano L.
- Villanueva C.
- Ibanez-Samaniego L.
- Silva-Junior G.
- Martinez J.
- Genesca J.
- Trebicka J.
- Llop E.
- Palazon J. M.
- Castellote J.
- Rodrigues S.
- Gluud L. L.
- Ferreira C. N.
- Barcelo R.
- Canete N.
- Rodriguez M.
- Ferlitsch A.
- Mundi J. L.
- Gronbaek H.
- Hernandez-Guerra M.
- Sassatelli R.
- Dell'Era A.
- Senzolo M.
- Romero-Gomez M.
- Casas M.
- Masnou H.
- Primignani M.
- Krag A.
- Calleja J. L.
- Jansen C.
- Robic M. A.
- Conejo I.
- Catalina M. -V.
- Albillos A.
- Alvarado E.
- Guardascione M. A.
- Tantau M.
- Zuo L.
- Zhu X.
- Zhao J.
- Xue H.
- Jiang Z.
- Zhuge Y.
- Zhang C.
- Sun J.
- Ding P.
- Ren W.
- Li Y.
- Zhang K.
- Zhang W.
- He C.
- Zhong J.
- Peng Q.
- Ma F.
- Luo J.
- Zhang M.
- Wang G.
- Sun M.
- Dong J.
- Bai W.
- Guo W.
- Wang Q.
- Yuan X.
- Wang Z.
- Yu T.
- Luo B.
- Li X.
- Yuan J.
- Han N.
- Zhu Y.
- Niu J.
- Li K.
- Yin Z.
- Nie Y.
- Fischer P.
- Horia Stefanescu
- Pop A.
- Laursen S. B.
- Turon F.
- Baiges A.
- Ferrusquia-Acosta J.
- Magaz M.
- Cerda E.
- Tellez L.
- Allegretti G.
- Macedo G.
- Haldrup D.
- Santos P.
- Moura M.
- Reis D.
- Meireles L.
- Sousa P.
- Alexandrino P.
- Navascues C.
- Augustin S.
- La Mura V.
- Banares R.
- Diaz R.
- Gomez M. L.
- Ripoll C.
DOIAbstract
Background & Aims: Compared with drugs plus endoscopy, placement of transjugular portosystemic shunt within 72 hours of admission to the hospital (early or preventive transjugular intrahepatic portosystemic shunt [TIPS], also called preemptive TIPS) increases the proportion of high-risk patients with cirrhosis and acute variceal bleeding who survive for 1 year. However, the benefit of preemptive TIPS is less clear for patients with a Child-Pugh score of B and active bleeding (CP-B+AB). We performed an individual data meta-analysis to assess the efficacy of preemptive TIPS in these patients and identify factors associated with reduced survival of patients receiving preemptive TIPS. Methods: We searched publication databases for randomized co...
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