International audienceContext. CO isotopologue transitions are routinely observed in molecular clouds for the purpose of probing the column density of the gas and the elemental ratios of carbon and oxygen, in addition to tracing the kinematics of the environment.Aims. Our study is aimed at estimating the abundances, excitation temperatures, velocity field, and velocity dispersions of the three main CO isotopologues towards a subset of the Orion B molecular cloud, which includes IC 434, NGC 2023, and the Horsehead pillar.Methods. We used the Cramer Rao bound (CRB) technique to analyze and estimate the precision of the physical parameters in the framework of local-thermodynamic-equilibrium (LTE) excitation and radiative transfer with added wh...