Fructose-6-phosphate,2-kinase/fructose-2,6-bisphosphatase (Fru-6-P,2- kinase/Fru-2,6-Pase) is a bifunctional enzyme, catalyzing the interconversion of β-D-fructose-6-phosphate (Fru-6-P) and fructose-2,6-bisphosphate (Fru- 2,6-P2) at distinct active sites. A mutant rat testis isozyme with an alanine replacement for the catalytic histidine (H256A) in the Fru-2,6-Pase domain retains 17% of the wild type activity (Mizuguchi, H., Cook, P. F., Tai, C-H., Hasemann, C. A., and Uyeda, K. (1998) J. Biol. Chem. 274, 2166- 2175). We have solved the crystal structure of H256A to a resolution of 2.4 Å by molecular replacement. Clear electron density for Fru-6-P is found at the Fru-2,6-Pase active site, revealing the important interactions in substrate/pr...
Fructose-1,6-bisphosphatase, a key enzyme in gluconeogenesis, is subject to metabolic regulation. Th...
Fructose-1, 6-bisphosphate (D-fructose-1, 6-bisphosphate 1-phosphohydrolase; EC 3. 1. 3; FBPase) is ...
To understand the mechanism by which the activity of the 6-phosphofructo-2-kinase (6PF-2K) of chicke...
AbstractBackground Glucose homeostasis is maintained by the processes of glycolysis and gluconeogene...
To understand the molecular basis of a phosphoryl transfer reaction catalyzed by the 6-phosphofructo...
In a structural model of the 2-kinase domain of the bifunctional enzyme 6-phosphofructo-2-kinase/fru...
The crystal structures of the human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in th...
The molecular basis of fructose-2,6-bisphosphatase (F-2,6-P 2ase) of 6-phosphofructo-2-kinase/fructo...
Sequence alignment and modeling of the 2-kinase domain of the liver bifunctional enzyme, 6-phosphofr...
The roles of Arg-104 and Arg-225 located in the 2-kinase domain of the bifunctional enzyme 6-phospho...
Since the discovery of Fru-2.6-P2 more than ten years ago, a great deal has been learned about its r...
Fru-2,6-P2 (fructose 2,6-bisphosphate) is a signal molecule that controls glycolysis. Since its disc...
Sequencing of an open reading frame 450 bp downstream from the yeast VPS35 gene revealed a putative ...
All known 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isozymes contain a sequence (GX4GK(S/...
Fructose-1,6-bisphosphatase, a key enzyme in gluconeogenesis, is subject to metabolic regulation. Th...
Fructose-1,6-bisphosphatase, a key enzyme in gluconeogenesis, is subject to metabolic regulation. Th...
Fructose-1, 6-bisphosphate (D-fructose-1, 6-bisphosphate 1-phosphohydrolase; EC 3. 1. 3; FBPase) is ...
To understand the mechanism by which the activity of the 6-phosphofructo-2-kinase (6PF-2K) of chicke...
AbstractBackground Glucose homeostasis is maintained by the processes of glycolysis and gluconeogene...
To understand the molecular basis of a phosphoryl transfer reaction catalyzed by the 6-phosphofructo...
In a structural model of the 2-kinase domain of the bifunctional enzyme 6-phosphofructo-2-kinase/fru...
The crystal structures of the human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in th...
The molecular basis of fructose-2,6-bisphosphatase (F-2,6-P 2ase) of 6-phosphofructo-2-kinase/fructo...
Sequence alignment and modeling of the 2-kinase domain of the liver bifunctional enzyme, 6-phosphofr...
The roles of Arg-104 and Arg-225 located in the 2-kinase domain of the bifunctional enzyme 6-phospho...
Since the discovery of Fru-2.6-P2 more than ten years ago, a great deal has been learned about its r...
Fru-2,6-P2 (fructose 2,6-bisphosphate) is a signal molecule that controls glycolysis. Since its disc...
Sequencing of an open reading frame 450 bp downstream from the yeast VPS35 gene revealed a putative ...
All known 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isozymes contain a sequence (GX4GK(S/...
Fructose-1,6-bisphosphatase, a key enzyme in gluconeogenesis, is subject to metabolic regulation. Th...
Fructose-1,6-bisphosphatase, a key enzyme in gluconeogenesis, is subject to metabolic regulation. Th...
Fructose-1, 6-bisphosphate (D-fructose-1, 6-bisphosphate 1-phosphohydrolase; EC 3. 1. 3; FBPase) is ...
To understand the mechanism by which the activity of the 6-phosphofructo-2-kinase (6PF-2K) of chicke...