Versatile bioactive and antibacterial coating system based on silica, gentamicin, and chitosan: Improving early stage performance of titanium implants

The aim of this work is to develop and characterize a multifunctional and dual surface coating system for titanium orthopedic implants by applying two different cost-effective, scalable, and non-complex coating technologies (spray and electrophoretic deposition). The first deposit is formed by a sprayed hybrid sol-gel layer combined with bioactive glass particles (45S5, BG), and the outer part of the dual coating consists of a chitosan-gelatin/silica (Si) - antibiotic (gentamicin, Ge) composite layer applied by electrophoretic deposition. The application of sol-gel enclosed BG drops onto the surface was done to enhance the bioactivity of the double-layered surface coating system. After the BG is dissolved, thus generating a calcium‑silicon rich medium, the re-deposition of hydroxyl‑carbonate apatite occurs. Regarding the antibacterial inhibition properties, antibacterial activity to both strains used (S. aureus and E. coli) was obtained for the chitosan/gelatin/Si[sbnd]Ge nanoparticle coatings on titanium substrates, showing a large inhibition area around the samples. Both the bare Ti samples and the coatings with chitosan/gelatin matrix did not successfully inhibit bacterial growth. As expected, the presence of silica-based glasses and coatings based on amorphous silica enhanced cell viability. The deposition of BG was done with the aim of extending the bioactive effect of the system, considering the presence of a porous degradable organic layer deposited on top, which was shown to be partially degraded after 7 days. The sol gel sprayed BG layer combined with chitosan/gelatin biopolymers filled with Si[sbnd]Ge nanoparticles presents a suitable technology to generate bioactive and antibacterial surfaces to enhance Ti implant performance.Fil: Ballarre, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Aydemir, T.. Friedrich Alexander Universitat; AlemaniaFil: Liverani, L.. Institute Of Biomaterials - Friedrich Alexander Univers; AlemaniaFil: Roether, Judith A.. Friedrich Alexander Universitat; AlemaniaFil: Goldmann, W.H.. Friedrich Alexander Universitat; AlemaniaFil: Boccaccini, Aldo R.. Institute Of Biomaterials - Friedrich Alexander Univers; Alemani