Myocyte apoptosis is central to myocardial dysfunction following ischemia/reperfusion (I/R) and during the transition from hypertrophy to heart failure. Focal adhesion kinase (FAK), a non-receptor tyrosine kinase regulates adhesion-dependent survival signals and unopposed FAK activation has been linked to tumor development. We previously showed that conditional myocyte-specific deletion of FAK (MFKO) in the adult heart did not affect basal cardiomyocyte survival or cardiac function but led to dilated cardiomyopathy and heart failure following pressure overload. In the present study, we sought to determine if FAK functions to limit stress-induced cardiomyocyte apoptosis. We reasoned that (I/R), which stimulates robust apoptotic cell death, m...
Focal adhesion kinase (FAK), a broadly expressed non-receptor tyrosine kinase which transduces signa...
Abstract—Hypertrophy is a critical event in the onset of failure in chronically overloaded hearts. F...
AbstractNeuregulin (Nrg)/ErbB and integrin signaling pathways are critical for the normal function o...
Myocyte apoptosis is central to myocardial dysfunction following ischemia/reperfusion (I/R) and duri...
We previously reported that cardiac-restricted deletion of focal adhesion kinase (FAK) exacerbated m...
Objective—We previously reported that cardiac-restricted deletion of focal adhesion kinase (FAK) exa...
Focal adhesion kinase (FAK) is a ubiquitously expressed cytoplasmic tyrosine kinase strongly activat...
The cardiomyocyte phenotypic switch from a proliferative to terminally differentiated state impacts ...
Abstract—Focal adhesion kinase (FAK) is a ubiquitously expressed cytoplasmic tyrosine kinase strongl...
Focal adhesion kinase (FAK) is a broadly expressed tyrosine kinase implicated in cellular functions ...
Cardiac fibrosis in post-myocardial infarction (MI), seen in both infarcted and non-infarcted myocar...
Background-—Our laboratory has previously demonstrated the importance of a cytoskeletal-based surviv...
Clinical application of potent anthracycline anticancer drugs, especially doxorubicin (DOX), is limi...
Focal adhesion kinase (FAK) is a critical mediator of matrix- and growth factor-induced signaling du...
Migration and proliferation of cardiac fibroblasts (CFs) play an important role in the myocardial re...
Focal adhesion kinase (FAK), a broadly expressed non-receptor tyrosine kinase which transduces signa...
Abstract—Hypertrophy is a critical event in the onset of failure in chronically overloaded hearts. F...
AbstractNeuregulin (Nrg)/ErbB and integrin signaling pathways are critical for the normal function o...
Myocyte apoptosis is central to myocardial dysfunction following ischemia/reperfusion (I/R) and duri...
We previously reported that cardiac-restricted deletion of focal adhesion kinase (FAK) exacerbated m...
Objective—We previously reported that cardiac-restricted deletion of focal adhesion kinase (FAK) exa...
Focal adhesion kinase (FAK) is a ubiquitously expressed cytoplasmic tyrosine kinase strongly activat...
The cardiomyocyte phenotypic switch from a proliferative to terminally differentiated state impacts ...
Abstract—Focal adhesion kinase (FAK) is a ubiquitously expressed cytoplasmic tyrosine kinase strongl...
Focal adhesion kinase (FAK) is a broadly expressed tyrosine kinase implicated in cellular functions ...
Cardiac fibrosis in post-myocardial infarction (MI), seen in both infarcted and non-infarcted myocar...
Background-—Our laboratory has previously demonstrated the importance of a cytoskeletal-based surviv...
Clinical application of potent anthracycline anticancer drugs, especially doxorubicin (DOX), is limi...
Focal adhesion kinase (FAK) is a critical mediator of matrix- and growth factor-induced signaling du...
Migration and proliferation of cardiac fibroblasts (CFs) play an important role in the myocardial re...
Focal adhesion kinase (FAK), a broadly expressed non-receptor tyrosine kinase which transduces signa...
Abstract—Hypertrophy is a critical event in the onset of failure in chronically overloaded hearts. F...
AbstractNeuregulin (Nrg)/ErbB and integrin signaling pathways are critical for the normal function o...