In 2015, 8.8 million of death were due to cancer making it an important cause of death in the world. The necessity to develop new anticancer treatments led to the search and discovery of new biological targets, such as Asf1, a histone chaperone protein of H3-H4 which is overexpressed in cancer cells, in particular in breast cancer. This protein plays a role in different biological processes in cells through protein-protein interactions (PPIs). During this thesis, we developed an original strategy to design inhibitors of PPIs with urea-based peptidomimetics. These foldamers are able to fold into stable 2.5-helix reminiscent to the natural α-helix. Designed urea-based foldamers have been synthesized as hybrid oligomers consisting of α-peptide...
Les structures hélicoïdales, outre leur rôle structural dans les protéines, sont aussi présentes aux...
Les α-hélices sont des éléments clés de la reconnaissance biomoléculaire, comme en témoigne le fait ...
Protein-protein interactions (PPI) have a key role in physiological processes. The inhibition of the...
In 2015, 8.8 million of death were due to cancer making it an important cause of death in the world....
Avec 8,8 millions de décès dénombrés en 2015, le cancer est l’une des plus grandes causes de mortali...
Sequence-specific oligomers with predictable folding patterns, i.e., foldamers, provide new opportun...
Sequence-specific oligomers with predictable folding patterns, i.e. foldamers provide new opportunit...
ASF1 est un chaperon d’histones H3-H4 impliqué dans de nombreux cancers. Comme bon nombre de protéin...
Α-Helices are key elements of biomolecular recognition, as reflected by the fact that a large fracti...
International audienceAnti-silencing function 1 (ASF1) is a conserved H3-H4 histone chaperone involv...
Les structures hélicoïdales, outre leur rôle structural dans les protéines, sont aussi présentes aux...
Les α-hélices sont des éléments clés de la reconnaissance biomoléculaire, comme en témoigne le fait ...
Protein-protein interactions (PPI) have a key role in physiological processes. The inhibition of the...
In 2015, 8.8 million of death were due to cancer making it an important cause of death in the world....
Avec 8,8 millions de décès dénombrés en 2015, le cancer est l’une des plus grandes causes de mortali...
Sequence-specific oligomers with predictable folding patterns, i.e., foldamers, provide new opportun...
Sequence-specific oligomers with predictable folding patterns, i.e. foldamers provide new opportunit...
ASF1 est un chaperon d’histones H3-H4 impliqué dans de nombreux cancers. Comme bon nombre de protéin...
Α-Helices are key elements of biomolecular recognition, as reflected by the fact that a large fracti...
International audienceAnti-silencing function 1 (ASF1) is a conserved H3-H4 histone chaperone involv...
Les structures hélicoïdales, outre leur rôle structural dans les protéines, sont aussi présentes aux...
Les α-hélices sont des éléments clés de la reconnaissance biomoléculaire, comme en témoigne le fait ...
Protein-protein interactions (PPI) have a key role in physiological processes. The inhibition of the...