Add to ORKGThis thesis presents the synthesis of several structural analogues of the immunosuppressant compound THI. A number of the synthesised analogues were found to have higher levels of biological activity of the same type as THI. Chapter 1 presents an introduction and summary of some of the fundamental principles behind immunosuppression and the modes of action of a range of known commercial immunosuppressants. This chapter also looks at the role of immunosuppression in modern medicine and presents some potential new immunosuppressants yet to reach the commercial market. The final part of the chapter provides an introduction to, and background of THI, which leads into the aims of the project. Chapter 2 presents the synthesis of five-carbon side ...
These overviews signify a study covering the literature on thiazole derivatives in heterocyclic chem...
Heterocycles are one of the most important class of molecules in medicinal chemistry. These compound...
Thiazole is a well known five membered heterocyclic compound. Various methods have been w...
The synthesis of four of the diastereoisomers of 2-acetyl-5-(1,2,3,4-tetrahydroxybutyl)thiazole and ...
Heterocyclic structures are of fundamental importance in drug discovery and the vast majority of the...
Herein we describe the synthesis and in vitro and in vivo activity of thiazolo[5,4-d]pyrimidines as ...
A method for preparing the thiazole analogue 2 of the biologically active compound (1R,2S,3R)-2-acet...
In this paper, a series of imidazo[2,l-b][1,3,4]thiadiazoles have been prepared by reacting 2-amino-...
Abstract Thiazolidinediones are sulfur containing pentacyclic compounds that are widely found throug...
For many decades, the thiazole moiety has been an important heterocycle in the world of chemistry. T...
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and ...
Thiazole is a well-known five-membered heterocyclic compound. Various methods have been worked out f...
Thiazole is a nitrogen and sulphur containing heterocyclic five membered aromatic ring. Thiazole der...
Background: Thiazole is widely investigated bioactive scaffold and dynamic tool in medicinal chemist...
Abstract Background The synthesis of new thiazole derivatives is very important because of their div...
These overviews signify a study covering the literature on thiazole derivatives in heterocyclic chem...
Heterocycles are one of the most important class of molecules in medicinal chemistry. These compound...
Thiazole is a well known five membered heterocyclic compound. Various methods have been w...
The synthesis of four of the diastereoisomers of 2-acetyl-5-(1,2,3,4-tetrahydroxybutyl)thiazole and ...
Heterocyclic structures are of fundamental importance in drug discovery and the vast majority of the...
Herein we describe the synthesis and in vitro and in vivo activity of thiazolo[5,4-d]pyrimidines as ...
A method for preparing the thiazole analogue 2 of the biologically active compound (1R,2S,3R)-2-acet...
In this paper, a series of imidazo[2,l-b][1,3,4]thiadiazoles have been prepared by reacting 2-amino-...
Abstract Thiazolidinediones are sulfur containing pentacyclic compounds that are widely found throug...
For many decades, the thiazole moiety has been an important heterocycle in the world of chemistry. T...
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and ...
Thiazole is a well-known five-membered heterocyclic compound. Various methods have been worked out f...
Thiazole is a nitrogen and sulphur containing heterocyclic five membered aromatic ring. Thiazole der...
Background: Thiazole is widely investigated bioactive scaffold and dynamic tool in medicinal chemist...
Abstract Background The synthesis of new thiazole derivatives is very important because of their div...
These overviews signify a study covering the literature on thiazole derivatives in heterocyclic chem...
Heterocycles are one of the most important class of molecules in medicinal chemistry. These compound...
Thiazole is a well known five membered heterocyclic compound. Various methods have been w...