Dlg (Discs large), Scrib (Scribble) and Lgl (Lethal giant larvae) are evolutionarily conserved components of a common genetic pathway that link the seemingly disparate functions of cell polarity and cell proliferation in epithelial cells. dlg, scrib and lgl have been identified as tumour suppressor genes in Drosophila, mutations of which cause similar phenotypes, involving disruption of cell polarity and neoplastic overgrowth of tissues. The molecular mechanisms by which Dlg, Scrib and Lgl proteins regulate cell proliferation are not clear, but there is some evidence that epithelial polarisation is required for this regulation. Dlg, Scrib and Lgl are highly conserved between human and Drosophila, and we discuss evidence that these proteins ...
This article belongs to the Special Issue Basic and Translational Models of Cooperative Oncogenesis....
The Drosophila model system has been at the forefront of many scientific discoveries. Studies of tum...
The Drosophila model system has been at the forefront of many scientific discoveries. Studies of tum...
Loss of cell polarity is one of the hallmarks of malignant carcinomas. Most of the understanding abo...
Loss of polarity is one of the earliest hallmarks of epithelial neoplasia and leads to aberrant comm...
Cell polarity and cell proliferation can be coupled in animal tissues, but how they are coupled is n...
Cell polarity and cell proliferation can be coupled in animal tissues, but how they are coupled is n...
Scribble (scrib), discs large (dlg) and lethal giant larvae (lgl) encode proteins that regulate cell...
Although the Scribble polarity module has long been known as a key regulator of apicobasal polarity,...
AbstractThe Drosophila tumor suppressor genes scribble, discs large and lethal giant larvae appear t...
none3siLoss of cell polarity is a prominent feature of epithelial cancers. Several tumour-suppressor...
none3siLoss of cell polarity is a prominent feature of epithelial cancers. Several tumour-suppressor...
AbstractThe Drosophila tumor suppressor genes scribble, discs large and lethal giant larvae appear t...
The compartmentalized domains of polarized epithelial cells arise from mutually antagonistic actions...
none3siLoss of cell polarity is a prominent feature of epithelial cancers. Several tumour-suppressor...
This article belongs to the Special Issue Basic and Translational Models of Cooperative Oncogenesis....
The Drosophila model system has been at the forefront of many scientific discoveries. Studies of tum...
The Drosophila model system has been at the forefront of many scientific discoveries. Studies of tum...
Loss of cell polarity is one of the hallmarks of malignant carcinomas. Most of the understanding abo...
Loss of polarity is one of the earliest hallmarks of epithelial neoplasia and leads to aberrant comm...
Cell polarity and cell proliferation can be coupled in animal tissues, but how they are coupled is n...
Cell polarity and cell proliferation can be coupled in animal tissues, but how they are coupled is n...
Scribble (scrib), discs large (dlg) and lethal giant larvae (lgl) encode proteins that regulate cell...
Although the Scribble polarity module has long been known as a key regulator of apicobasal polarity,...
AbstractThe Drosophila tumor suppressor genes scribble, discs large and lethal giant larvae appear t...
none3siLoss of cell polarity is a prominent feature of epithelial cancers. Several tumour-suppressor...
none3siLoss of cell polarity is a prominent feature of epithelial cancers. Several tumour-suppressor...
AbstractThe Drosophila tumor suppressor genes scribble, discs large and lethal giant larvae appear t...
The compartmentalized domains of polarized epithelial cells arise from mutually antagonistic actions...
none3siLoss of cell polarity is a prominent feature of epithelial cancers. Several tumour-suppressor...
This article belongs to the Special Issue Basic and Translational Models of Cooperative Oncogenesis....
The Drosophila model system has been at the forefront of many scientific discoveries. Studies of tum...
The Drosophila model system has been at the forefront of many scientific discoveries. Studies of tum...