Topics
IC50Software
P-glycoproteinBiomolecule
agarChemical compound
KBOrganisation
apoptosisAnatomical structure
Mechanisms of growth inhibition by the novel marine compound dehydrothyrsiferol (DHT) were investigated in a sensitive and an MDR+ human epidermoid cancer cell line. DHT was found to circumvent multidrug resistance mediated by P-glycoprotein. Cell cycle analysis revealed an accumulation in S-phase. The anchorage independent clonogenic growth in soft agar was not significantly reduced at IC50 concentrations. Reduced cell growth caused by induction of apoptotic or necrotic cell death could not be verified. Therefore, cell proliferation during an incubation period of five days was measured and found to be significantly reduced. We conclude that growth inhibition by dehydrothyrsiferol in KB cancer cells is not mediated by apoptosis but by growt...
<div><p>Triple-negative breast cancer is associated with poor prognosis because of a high rate of tu...
Soft tissue sarcomas (STS) represent a rare group of malignant tumors that frequently exhibit chemot...
Abstract Cancer is a leading cause of death in industrialized countries. Although mortality rates...
Mechanisms of growth inhibition by the novel marine compound dehydrothyrsiferol (DHT) were investiga...
The cytotoxic marine red algal metabolite thyrsiferol (1) was found to inhibit hypoxia-induced hypox...
The phenomenon of multidrug resistant (MDR) ovarian cancer is a major obstacle to successful cancer ...
The potential anti-neoplastic activity of terpenoids is of continued interest. In this study, we inv...
This article is hosted on a website external to the CBCRA Open Access Archive. Selecting “View/Open...
Soft tissue sarcomas (STS) represent a rare group of malignant tumors that frequently exhibit chemot...
Cells can respond to DNA damage by activating checkpoints that delay cell cycle progression and allo...
In the present study we have explored the sensitivity of ovarian cancer cells to the synthetic trite...
Dihydrosinularin (DHS) is an analog of soft coral-derived sinularin; however, the anticancer effects...
Triple-negative breast cancer is associated with poor prognosis because of a high rate of tumor recu...
Docosahexaenoic acid (DHA; 22:6n-3) is an essential omega-3 polyunsaturated fatty acid important to ...
11-Dehydrosinulariolide, an active compound that is isolated from the cultured soft coral Sinularia ...
<div><p>Triple-negative breast cancer is associated with poor prognosis because of a high rate of tu...
Soft tissue sarcomas (STS) represent a rare group of malignant tumors that frequently exhibit chemot...
Abstract Cancer is a leading cause of death in industrialized countries. Although mortality rates...
Mechanisms of growth inhibition by the novel marine compound dehydrothyrsiferol (DHT) were investiga...
The cytotoxic marine red algal metabolite thyrsiferol (1) was found to inhibit hypoxia-induced hypox...
The phenomenon of multidrug resistant (MDR) ovarian cancer is a major obstacle to successful cancer ...
The potential anti-neoplastic activity of terpenoids is of continued interest. In this study, we inv...
This article is hosted on a website external to the CBCRA Open Access Archive. Selecting “View/Open...
Soft tissue sarcomas (STS) represent a rare group of malignant tumors that frequently exhibit chemot...
Cells can respond to DNA damage by activating checkpoints that delay cell cycle progression and allo...
In the present study we have explored the sensitivity of ovarian cancer cells to the synthetic trite...
Dihydrosinularin (DHS) is an analog of soft coral-derived sinularin; however, the anticancer effects...
Triple-negative breast cancer is associated with poor prognosis because of a high rate of tumor recu...
Docosahexaenoic acid (DHA; 22:6n-3) is an essential omega-3 polyunsaturated fatty acid important to ...
11-Dehydrosinulariolide, an active compound that is isolated from the cultured soft coral Sinularia ...
<div><p>Triple-negative breast cancer is associated with poor prognosis because of a high rate of tu...
Soft tissue sarcomas (STS) represent a rare group of malignant tumors that frequently exhibit chemot...
Abstract Cancer is a leading cause of death in industrialized countries. Although mortality rates...
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