Add to ORKGThe principle objective of this investigation was to synthesize a series of modified purines and their corresponding nucleosides, similar in structure to the so-called 'Y�-base. These compounds were characterized and evaluated as potential antiviral agents. A series of modified 5,9-dihydro-9-oxo-lH-imidazo[1.2a]purines and their corresponding nucleosides were synthesized in moderate yields using revised procedures of Nakanishi. These compounds were assayed for antiviral activity and cytotoxicity. These compounds were nontoxic at low concentration and were moderately effective against the herpes simplex virus type I
The synthetic analogues of the natural 2’-deoxyribonucleosides, linked by phosphodiester groups in n...
The preparation of a series of novel 6-(β-D-ribofuranosyl)-2-alkyl/aryl-6H-imidazo[1,2-c]pyrimidin-5...
A series of base-modified pyrimidine 3'-azido-2',3'-dideoxynucleosides and 3'-substituted purine and...
A wide variety of nucleosides have been shown to inhibit human immunodeficiency virus (HIV) which is...
Les analogues synthétiques des nucléosides naturels constituant des acides nucléiques occupent une p...
Every year, hundreds of new nucleoside analogues are obtained in laboratories around the world. As e...
Nucleoside analogues are an important class of antimetabolites, used both as anticancer and antivira...
A small series of 5-(hetero)aryl-modified nucleoside phosphonates was synthesized via an 8-step proc...
5-Phosphate triesters were derived from the nucleosides 882C (1), acyclovir (2), 5'-hydroxyethoxymet...
RNA viruses exhibit extraordinarily high mutation rates during genome replication. Nonnatural ribonu...
A series of tritylated and dimethoxytritylated analogues of selected pyrimidine and purine nucleosid...
Purines are one of the most ubiquitous heterocyclic ring systems in nature and consequently, they ar...
The goal of this thesis was to synthesize certain restricted pyrimidine acyclic nucleosides (R$\sb{\...
DoctorNucleosides are very active and important biomolecules. Most people think that the main role o...
Nucleoside analogues play an important role in antiviral, antibacterial and antineoplastic chemother...
The synthetic analogues of the natural 2’-deoxyribonucleosides, linked by phosphodiester groups in n...
The preparation of a series of novel 6-(β-D-ribofuranosyl)-2-alkyl/aryl-6H-imidazo[1,2-c]pyrimidin-5...
A series of base-modified pyrimidine 3'-azido-2',3'-dideoxynucleosides and 3'-substituted purine and...
A wide variety of nucleosides have been shown to inhibit human immunodeficiency virus (HIV) which is...
Les analogues synthétiques des nucléosides naturels constituant des acides nucléiques occupent une p...
Every year, hundreds of new nucleoside analogues are obtained in laboratories around the world. As e...
Nucleoside analogues are an important class of antimetabolites, used both as anticancer and antivira...
A small series of 5-(hetero)aryl-modified nucleoside phosphonates was synthesized via an 8-step proc...
5-Phosphate triesters were derived from the nucleosides 882C (1), acyclovir (2), 5'-hydroxyethoxymet...
RNA viruses exhibit extraordinarily high mutation rates during genome replication. Nonnatural ribonu...
A series of tritylated and dimethoxytritylated analogues of selected pyrimidine and purine nucleosid...
Purines are one of the most ubiquitous heterocyclic ring systems in nature and consequently, they ar...
The goal of this thesis was to synthesize certain restricted pyrimidine acyclic nucleosides (R$\sb{\...
DoctorNucleosides are very active and important biomolecules. Most people think that the main role o...
Nucleoside analogues play an important role in antiviral, antibacterial and antineoplastic chemother...
The synthetic analogues of the natural 2’-deoxyribonucleosides, linked by phosphodiester groups in n...
The preparation of a series of novel 6-(β-D-ribofuranosyl)-2-alkyl/aryl-6H-imidazo[1,2-c]pyrimidin-5...
A series of base-modified pyrimidine 3'-azido-2',3'-dideoxynucleosides and 3'-substituted purine and...