International audienceAging is the major risk factor for the development of chronic diseases. After decades of research focused on extending lifespan, current efforts seek primarily to promote healthy aging. Recent advances suggest that biological processes linked to aging are more reliable than chronological age to account for an individual's functional status, i.e. frail or robust. It is becoming increasingly apparent that biological aging may be detectable as a progressive loss of resilience much earlier than the appearance of clinical signs of frailty. In this context, the INSPIRE program was built to identify the mechanisms of accelerated aging and the early biological signs predicting frailty and pathological aging. To address this is...
Little is known whether frailty assessments in mice are capable of distinguishing important characte...
Current concepts regarding the biology of aging are primarily based on studies aimed at identifying ...
Calorie restriction (CR) extends lifespan and retards age-related chronic diseases in most species. ...
International audienceAging is the major risk factor for the development of chronic diseases. After ...
Human life expectancy has increased dramatically in the last century and as a result also the preval...
The relationship between chronological age (lifespan) and biological age (healthspan) varies amongst...
The identification of genes and interventions that slow or reverse aging is hampered by the lack of ...
Mice are an ideal mammalian model for studying the genetics of aging: considerable resources are ava...
Aging is associated with distinct phenotypical, physiological, and functional changes, leading to di...
Over the last two centuries, there has been a significant increase in average lifespan expectancy in...
Traditionally, biomarkers of aging are classified as either pro-longevity or antilongevity. Using lo...
Understanding the source of genetic variation in aging and using this variation to define the molecu...
Aging is broadly defined as the deterioration of bodily tissues over time. Excluding death due to i...
Biomarkers of agingwould be highly desirable, but so far, a definitive panel of biomarkers to predic...
Aging is characterized generally by progressive and overall physiological decline of functions and i...
Little is known whether frailty assessments in mice are capable of distinguishing important characte...
Current concepts regarding the biology of aging are primarily based on studies aimed at identifying ...
Calorie restriction (CR) extends lifespan and retards age-related chronic diseases in most species. ...
International audienceAging is the major risk factor for the development of chronic diseases. After ...
Human life expectancy has increased dramatically in the last century and as a result also the preval...
The relationship between chronological age (lifespan) and biological age (healthspan) varies amongst...
The identification of genes and interventions that slow or reverse aging is hampered by the lack of ...
Mice are an ideal mammalian model for studying the genetics of aging: considerable resources are ava...
Aging is associated with distinct phenotypical, physiological, and functional changes, leading to di...
Over the last two centuries, there has been a significant increase in average lifespan expectancy in...
Traditionally, biomarkers of aging are classified as either pro-longevity or antilongevity. Using lo...
Understanding the source of genetic variation in aging and using this variation to define the molecu...
Aging is broadly defined as the deterioration of bodily tissues over time. Excluding death due to i...
Biomarkers of agingwould be highly desirable, but so far, a definitive panel of biomarkers to predic...
Aging is characterized generally by progressive and overall physiological decline of functions and i...
Little is known whether frailty assessments in mice are capable of distinguishing important characte...
Current concepts regarding the biology of aging are primarily based on studies aimed at identifying ...
Calorie restriction (CR) extends lifespan and retards age-related chronic diseases in most species. ...