International audienceWe have recently shown a broad disparity of Natural Killer (NK) cell responses against leukemia highlighting good and bad responders resting on the Killer cell Immunoglobulin-like Receptors (KIR) and HLA genetics. In this study, we deeply studied KIR2D allele expression, HLA-C recognition and functional effect on NK cells in 108 blood donors in combining high-resolution KIR allele typing and multicolor flow cytometry. The KIR2DL1*003 allotype is associated with centromeric (cen) AA motif and confers the highest NK cell frequency, expression level and strength of KIR/HLA-C interactions compared to the KIR2DL1*002 and KIR2DL1*004 allotypes respectively associated with cenAB and BB motifs. KIR2DL2*001 and *003 allotypes n...
International audienceAlthough the key role of MHC-restricted T lymphocytes in hematopoietic stem ce...
Natural killer cells are thought to influence the outcome of hematopoietic stem cell transplant (HSC...
International audienceSince the mid-1990s, the biology and functions of natural killer (NK) cells ha...
International audienceWe have recently shown a broad disparity of Natural Killer (NK) cell responses...
AbstractAfter hematopoietic stem cell transplantation (HSCT), natural killer (NK) cell alloreactivit...
Haematopoietic stem cell transplantation (HSCT) often is a final treatment option for patients suffe...
Les cellules Natural Killer (NK) jouent un rôle important en greffes de cellules souches hématopoïét...
KIR2DL2 and KIR2DL3 segregate as alleles of a single locus in the centromeric motif of the killer ce...
International audienceWe analyzed 21 children with leukemia receiving haploidentical hematopoietic s...
We analyzed 21 children with leukemia receiving haploidentical hematopoietic stem cell transplantati...
Stem cell transplantation (SCT) from a healthy donor can be curative for patients with hematologic m...
BACKGROUND: Alloreactive NK cells play a role in tumor eradication after allogeneic HLA mismatched s...
International audienceNatural Killer (NK) cells are important effector cells in the early control of...
International audienceAlthough the key role of MHC-restricted T lymphocytes in hematopoietic stem ce...
Natural killer cells are thought to influence the outcome of hematopoietic stem cell transplant (HSC...
International audienceSince the mid-1990s, the biology and functions of natural killer (NK) cells ha...
International audienceWe have recently shown a broad disparity of Natural Killer (NK) cell responses...
AbstractAfter hematopoietic stem cell transplantation (HSCT), natural killer (NK) cell alloreactivit...
Haematopoietic stem cell transplantation (HSCT) often is a final treatment option for patients suffe...
Les cellules Natural Killer (NK) jouent un rôle important en greffes de cellules souches hématopoïét...
KIR2DL2 and KIR2DL3 segregate as alleles of a single locus in the centromeric motif of the killer ce...
International audienceWe analyzed 21 children with leukemia receiving haploidentical hematopoietic s...
We analyzed 21 children with leukemia receiving haploidentical hematopoietic stem cell transplantati...
Stem cell transplantation (SCT) from a healthy donor can be curative for patients with hematologic m...
BACKGROUND: Alloreactive NK cells play a role in tumor eradication after allogeneic HLA mismatched s...
International audienceNatural Killer (NK) cells are important effector cells in the early control of...
International audienceAlthough the key role of MHC-restricted T lymphocytes in hematopoietic stem ce...
Natural killer cells are thought to influence the outcome of hematopoietic stem cell transplant (HSC...
International audienceSince the mid-1990s, the biology and functions of natural killer (NK) cells ha...