Asymmetrische Synthese funktionalisierter Homoallyl- und Homopropargylalkohole mittels der Sulfoximin-Route

This dissertation describes new methods of asymmetric synthesis of diastereomeric and enantiomeric pure allylic alcohols. Via the sulfoximine-route by Gais et al. new chiral homoallyllic alcohols were synthesized. Elimination of the sulfoximine-group lead to optically pure homopropargylic alcohols. Via Nickel-catalysed cross-coupling reactions (homogenoes and heterogenoes Catalysis) of the homoallylic alcohols additional allylic silane- and allylic alcohol- groups were generated. Intramolecular cyclisation of the chiral allylic silanes with acetals yielded optically pure tetrasubstituted tetrahydrofurans