BACKGROUND: Accurate small molecule binding site information for a protein can facilitate studies in drug docking, drug discovery and function prediction, but small molecule binding site protein sequence annotation is sparse. The Small Molecule Interaction Database (SMID), a database of protein domain-small molecule interactions, was created using structural data from the Protein Data Bank (PDB). More importantly it provides a means to predict small molecule binding sites on proteins with a known or unknown structure and unlike prior approaches, removes large numbers of false positive hits arising from transitive alignment errors, non-biologically significant small molecules and crystallographic conditions that overpredict ion binding sites...
Abstract BACKGROUND: The identification of ligand binding sites is a key task in the annotation of...
Abstract BACKGROUND: The identification of ligand binding sites is a key task in the annotation of...
Protein–protein interactions are challenging targets for modulation by small molecules. Here, we pro...
BACKGROUND: Accurate small molecule binding site information for a protein can facilitate studies in...
Abstract Background The study of protein-small molecule interactions is vital for understanding prot...
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/...
The sc-PDB is a collection of 6 415 three-dimensional structures of binding sites found in the Prote...
Small molecules that modulate protein–protein interactions are of great interest for chemical biolog...
<div><p>The residue composition of a ligand binding site determines the interactions available for d...
The binding of small molecule ligands onto proteins is a key step in many cellular processes. Depend...
Determining the affinity of a ligand for a given protein is a crucial component of drug development ...
The Protein Data Bank (PDB) is the single global repository for three-dimensional struc-tures of bio...
We have developed a new computational algorithm for de novo identification of protein-ligand bindin...
Abstract BACKGROUND: The identification of ligand binding sites is a key task in the annotation of...
Protein–protein interactions are challenging targets for modulation by small molecules. Here, we pro...
Abstract BACKGROUND: The identification of ligand binding sites is a key task in the annotation of...
Abstract BACKGROUND: The identification of ligand binding sites is a key task in the annotation of...
Protein–protein interactions are challenging targets for modulation by small molecules. Here, we pro...
BACKGROUND: Accurate small molecule binding site information for a protein can facilitate studies in...
Abstract Background The study of protein-small molecule interactions is vital for understanding prot...
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/...
The sc-PDB is a collection of 6 415 three-dimensional structures of binding sites found in the Prote...
Small molecules that modulate protein–protein interactions are of great interest for chemical biolog...
<div><p>The residue composition of a ligand binding site determines the interactions available for d...
The binding of small molecule ligands onto proteins is a key step in many cellular processes. Depend...
Determining the affinity of a ligand for a given protein is a crucial component of drug development ...
The Protein Data Bank (PDB) is the single global repository for three-dimensional struc-tures of bio...
We have developed a new computational algorithm for de novo identification of protein-ligand bindin...
Abstract BACKGROUND: The identification of ligand binding sites is a key task in the annotation of...
Protein–protein interactions are challenging targets for modulation by small molecules. Here, we pro...
Abstract BACKGROUND: The identification of ligand binding sites is a key task in the annotation of...
Abstract BACKGROUND: The identification of ligand binding sites is a key task in the annotation of...
Protein–protein interactions are challenging targets for modulation by small molecules. Here, we pro...