The aim of the article is to describe the genesis, role, significance, conditions and effects of economic cooperation of the Visegrad Group countries in the European Union, with particular emphasis on their development after 2015. It presents the distinguishing features and specificity of the Group’s cooperation before accession to NATO and the EU in the context of the situation of Central Europe and other European post-communist countries, as well as the most important aspects of the political and economic potential of the V4 countries against the background of the EU and selected member states. Various aspects of their economic cooperation in the region are discussed, as well as the structural limitations of the role of the Viseg...