Mitochondrial stress triggers a pro-survival response through epigenetic modifications of nuclear DNA
- Mayorga, Lía
- Salassa, Betiana Nebaí
- Marzese, Diego Matías
- Loos, Mariana
- Eiroa, Hernán D.
- Lubieniecki, Fabiana
- Garcia Samartino, Clara
- Romano, Patricia Silvia
- Roque Moreno, Maria
DOIAbstract
Mitochondrial dysfunction represents an important cellular stressor and when intense and persistent cells must unleash an adaptive response to prevent their extinction. Furthermore, mitochondria can induce nuclear transcriptional changes and DNA methylation can modulate cellular responses to stress. We hypothesized that mitochondrial dysfunction could trigger an epigenetically mediated adaptive response through a distinct DNA methylation patterning. We studied cellular stress responses (i.e., apoptosis and autophagy) in mitochondrial dysfunction models. In addition, we explored nuclear DNA methylation in response to this stressor and its relevance in cell survival. Experiments in cultured human myoblasts revealed that intense mitochondrial ...
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