Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without family history of late-onset alzheimer’s disease
- Abulafia, Carolina Andrea
- Loewenstein, David
- Curiel-Cid, Rosie
- Duarte Abritta, Barbara Micaela
- Sanchez, Stella Maris
- Vigo, Daniel Eduardo
- Castro, Mariana Nair
- Drucaroff, Lucas Javier
- Vázquez, Silvia
- Sevlever, Gustavo
- Nemeroff, Charles B.
- Guinjoan, Salvador Martín
- Villarreal, Mirta Fabiana
DOIAbstract
Failure to recover from proactive semantic interference (frPSI) has been shown to be more sensitive than traditional cognitive measures in different populations with preclinical Alzheimer’s disease. The authors sought to characterize the structural and amyloid in vivo correlates of frPSI in cognitively normal offspring of patients with late-onset Alzheimer’s disease (O-LOAD), compared with individuals without a family history of neurodegenerative disorders (CS). The authors evaluated the LASSI-L, a test tapping frPSI and other types of semantic interference and delayed recall on the RAVLT, along with 3-T MRI volumetry and positron emission tomography Pittsburgh compound B, in 27 O-LOAD and 18 CS with equivalent age, sex, years of education,...
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