Effects of chronic Staphylococcus aureus infection on immunological parameters and functionality of macrophages isolated from bovine mammary secretions
- Renna, Maria Sol
- Silvestrini, Paula
- Beccaría, Camila
- Velazquez, Natalia Soledad
- Baravalle, Celina
- Engler, Carolina
- Pereyra, Elizabet Amanda Lorena
- Calvinho, Luis Fernando
- Dallard, Bibiana Elisabet
DOIAbstract
The aim of this study was to characterize the effects of chronic S. aureus intramammary infection (IMI) on local innate and adaptive immune response during active involution. Cows in late lactation that were either uninfected or with chronic naturally acquired S. aureus IMI were included in this study. The levels of interleukin (IL)-1β, IL-6 and IL-4 were significantly higher in mammary secretions of S. aureus-infected quarters compared with uninfected at d 7, 14 and 21 of involution. Lactoferrin (Lf), total IgG and S. aureus specific IgG1 levels were significantly lower in mammary secretions of infected quarters compared with uninfected during the first three weeks of involution. The amount of intracellular reactive oxygen species (ROS) pr...
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