Selective one-pot synthesis of asymmetric secondary amines via N-alkylation of nitriles with alcohols
- Segobia, Dario Jobino
- Trasarti, Andres Fernando
- Apesteguía, Sebastián
DOIAbstract
The synthesis of asymmetric secondary amines (ASA) is commonly achieved by N-alkylation of primaryamines with alcohols. Here, we investigated the ASA synthesis via the direct amination of alcohols withnitriles, which avoids the synthesis, separation and purification of the primary amines in a first step.Specifically, the ASA synthesis via N-alkylation of butyronitrile (BN) with primary (n-propanol, isobutanoland n-octanol) and secondary (2-propanol, 2-butanol and 2-octanol) alcohols was studied onSiO2-supported Co, Ni and Ru catalysts. Competitive BN hydrogenation-condensation reactions formeddibutylamine (the symmetric secondary amine) and tertiary amines as main secondary products. OnCo/SiO2, the ASA selectivities for BN/primary alcohol r...
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