Add to ORKGp15(INK4b), p16(INK4a) and O(6)-methylguanine DNA methyltransferase (MGMT) gene hypermethylation was studied in 22 patients with primary cutaneous T-cell lymphomas (CTCL). p15(INK4b) and p16(INK4a) inactivation is present in early and advanced disease and seems to be independent of disease stage. MGMT inactivation may play a pathogenetic role in a subset of CTCL
BACKGROUND AND OBJECTIVES: Aberrant promoter methylation targets CpG islands causing gene silencing....
The p16INK4a tumor suppressor gene can be inactivated by a variety of events including promoter hype...
There are few data on the molecular pathogenesis of cutaneous T cell lymphomas. A recent allelotypin...
The methylation status of the target promoter sequences of p15(INK4B) (p15) and O-6-methylguanine-DN...
The methylation status of the target promoter sequences of p15INK4B (p15) and O6-methylguanine-DNA m...
In this study, methylation-specific polymerase chain reaction was used to investigate the potential ...
The methylation status of p15(INK4b) (MTS2), p16(INK4a) (MTS1) and p14(ARF) (p16beta) was analyzed i...
AIMS: (1) To validate a quantitative real time methylation specific PCR assay (MethyLight) for the d...
In this study, methylation-specific polymerase chain reaction was used to investigate the role and p...
Primary cutaneous B cell lymphomas represent a distinct group of lymphoproliferative disorders that ...
International audienceAdult "T cell" acute lymphoblastic leukemia (T-ALL) is an aggressive hematolog...
INTRODUCTION: Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy of non-Hodgkin lymph...
The Sézary Syndrome (SS) is an aggressive CD4+ leukemic variant of cutaneous T-cell lymphoma. Epigen...
In cutaneous T-cell lymphomas (CTCLs) defects in Fas-mediated apoptosis have been suggested to be in...
Background: Mantle cell lymphoma (MCL) is genetically characterized by the t(11;14)(q13;q32) translo...
BACKGROUND AND OBJECTIVES: Aberrant promoter methylation targets CpG islands causing gene silencing....
The p16INK4a tumor suppressor gene can be inactivated by a variety of events including promoter hype...
There are few data on the molecular pathogenesis of cutaneous T cell lymphomas. A recent allelotypin...
The methylation status of the target promoter sequences of p15(INK4B) (p15) and O-6-methylguanine-DN...
The methylation status of the target promoter sequences of p15INK4B (p15) and O6-methylguanine-DNA m...
In this study, methylation-specific polymerase chain reaction was used to investigate the potential ...
The methylation status of p15(INK4b) (MTS2), p16(INK4a) (MTS1) and p14(ARF) (p16beta) was analyzed i...
AIMS: (1) To validate a quantitative real time methylation specific PCR assay (MethyLight) for the d...
In this study, methylation-specific polymerase chain reaction was used to investigate the role and p...
Primary cutaneous B cell lymphomas represent a distinct group of lymphoproliferative disorders that ...
International audienceAdult "T cell" acute lymphoblastic leukemia (T-ALL) is an aggressive hematolog...
INTRODUCTION: Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy of non-Hodgkin lymph...
The Sézary Syndrome (SS) is an aggressive CD4+ leukemic variant of cutaneous T-cell lymphoma. Epigen...
In cutaneous T-cell lymphomas (CTCLs) defects in Fas-mediated apoptosis have been suggested to be in...
Background: Mantle cell lymphoma (MCL) is genetically characterized by the t(11;14)(q13;q32) translo...
BACKGROUND AND OBJECTIVES: Aberrant promoter methylation targets CpG islands causing gene silencing....
The p16INK4a tumor suppressor gene can be inactivated by a variety of events including promoter hype...
There are few data on the molecular pathogenesis of cutaneous T cell lymphomas. A recent allelotypin...