Obesity (Silver Spring)

Objective:To evaluate weight changes after cessation of the 10-year intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study. We hypothesized that ILI participants would be more likely to gain weight during the 2-year observational period following termination of weight-loss-maintenance counseling than would participants in the Diabetes Support and Education (DSE) control group.Methods:Look AHEAD was an RCT that compared the effects of ILI and DSE on cardiovascular morbidity and mortality in participants with overweight/obesity and type 2 diabetes. Look AHEAD was converted to an observational study in September 2012.Results:Two years after the EOI, ILI and DSE participants lost a mean\ub1SE of 1.2\ub10.2 kg and 1.8\ub10.2 kg, respectively (p=0.003). Thirty-one percent of ILI and 23.9% of DSE participants gained 652% (p