Add to ORKGThe discovery and design of biologically important RNA molecules is outpacing three-dimensional structural characterization. Here, we demonstrate that cryo-electron microscopy can routinely resolve maps of RNA-only systems and that these maps enable subnanometer-resolution coordinate estimation when complemented with multidimensional chemical mapping and Rosetta DRRAFTER computational modeling. This hybrid 'Ribosolve' pipeline detects and falsifies homologies and conformational rearrangements in 11 previously unknown 119- to 338-nucleotide protein-free RNA structures: full-length Tetrahymena ribozyme, hc16 ligase with and without substrate, full-length Vibrio cholerae and Fusobacterium nucleatum glycine riboswitch aptamers with and without ...
The higher order structure of an RNA is often essential to its biological function, modulating its i...
<p>RNA, or ribonucleic acid, is one of the three biological macromolecule types essential for all kn...
The intricate network of interactions observed in RNA three-dimensional structures is often describe...
RNA cannot be considered anymore as a simple transfer molecule. On the contrary, a plethora of nonco...
RNA-Puzzles is a collective experiment in blind 3D RNA structure prediction. We report here a third ...
There is a growing body of low-resolution structural data that can be utilized to devise structural ...
Ribonucleic acid (RNA), as one of the essential macromolecules of life, plays an active role in gene...
none4Motivation: Over the recent years, the vision that RNA simply serves as information transfer mo...
RNA has emerged as a versatile and multi-faceted player in gene expression and the informational met...
Many problems in RNA and protein structures are related with their specific geometric properties. Ge...
RNA is not regarded anymore as a simple transfer molecule between DNA and proteins. Indeed, over the...
Modern molecular biology studies increasingly require customized computation support. This is especi...
RNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of RNA 3D structur...
Molecular modeling guided by experimentally-derived structural information is an attractive approach...
We present a Rosetta full-atom framework for predicting and designing the non-canonical motifs that ...
The higher order structure of an RNA is often essential to its biological function, modulating its i...
<p>RNA, or ribonucleic acid, is one of the three biological macromolecule types essential for all kn...
The intricate network of interactions observed in RNA three-dimensional structures is often describe...
RNA cannot be considered anymore as a simple transfer molecule. On the contrary, a plethora of nonco...
RNA-Puzzles is a collective experiment in blind 3D RNA structure prediction. We report here a third ...
There is a growing body of low-resolution structural data that can be utilized to devise structural ...
Ribonucleic acid (RNA), as one of the essential macromolecules of life, plays an active role in gene...
none4Motivation: Over the recent years, the vision that RNA simply serves as information transfer mo...
RNA has emerged as a versatile and multi-faceted player in gene expression and the informational met...
Many problems in RNA and protein structures are related with their specific geometric properties. Ge...
RNA is not regarded anymore as a simple transfer molecule between DNA and proteins. Indeed, over the...
Modern molecular biology studies increasingly require customized computation support. This is especi...
RNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of RNA 3D structur...
Molecular modeling guided by experimentally-derived structural information is an attractive approach...
We present a Rosetta full-atom framework for predicting and designing the non-canonical motifs that ...
The higher order structure of an RNA is often essential to its biological function, modulating its i...
<p>RNA, or ribonucleic acid, is one of the three biological macromolecule types essential for all kn...
The intricate network of interactions observed in RNA three-dimensional structures is often describe...