Add to ORKGIt is widely known that early estimates about the binding properties of drug candidates are important in the drug discovery process. Surface plasmon resonance (SPR) biosensors have become a standard tool for characterizing interactions between a great variety of biomolecules and it offers a unique opportunity to study binding activity. The aim of this project was to develop a SPR based assay for pre-screening of low molecular weight (LMW) drug compounds, to enable filtering away disturbing compounds when interacting with drugs. The interaction between 47 LMW compounds and biological ligands were investigated using the instrument BiacoreTM, which is based on SPR-technology
In the past decade, surface plasmon resonance (SPR) biosensor-based technology has been exploited mo...
AbstractSurface plasmon resonance (SPR) is one of the primary biophysical methods for the screening ...
Molecular interactions between proteins or between proteins and small molecules are pivotal events f...
It is widely known that early estimates about the binding properties of drug candidates are importan...
SPR (Surface Plasmon Resonance) biosensor instruments are more and more equipped to sensitively meas...
G-protein coupled receptors (GPCRs) are the primary target class of currently marketed drugs, accoun...
In the recent years, surface plasmon resonance (SPR) has become one of the major methods for studyin...
The majority of techniques currently employed to interrogate a biomolecular interaction require some...
Surface plasmon resonance (SPR) biosensors recently gained an important place in drug discovery. Her...
Surface plasmon resonance (SPR) is one of the most important techniques for the detection and the ch...
Surface plasmon resonance (SPR) is one of the primary biophysical methods for the screening of low m...
G-protein coupled receptors (GPCRs) are a class of drug targets of primary importance. However, rece...
Surface plasmon resonance (SPR) is one of the most important techniques for the detection and the ch...
In the past decade, surface plasmon resonance (SPR) biosensor-based technology has been exploited mo...
AbstractSurface plasmon resonance (SPR) is one of the primary biophysical methods for the screening ...
Molecular interactions between proteins or between proteins and small molecules are pivotal events f...
It is widely known that early estimates about the binding properties of drug candidates are importan...
SPR (Surface Plasmon Resonance) biosensor instruments are more and more equipped to sensitively meas...
G-protein coupled receptors (GPCRs) are the primary target class of currently marketed drugs, accoun...
In the recent years, surface plasmon resonance (SPR) has become one of the major methods for studyin...
The majority of techniques currently employed to interrogate a biomolecular interaction require some...
Surface plasmon resonance (SPR) biosensors recently gained an important place in drug discovery. Her...
Surface plasmon resonance (SPR) is one of the most important techniques for the detection and the ch...
Surface plasmon resonance (SPR) is one of the primary biophysical methods for the screening of low m...
G-protein coupled receptors (GPCRs) are a class of drug targets of primary importance. However, rece...
Surface plasmon resonance (SPR) is one of the most important techniques for the detection and the ch...
In the past decade, surface plasmon resonance (SPR) biosensor-based technology has been exploited mo...
AbstractSurface plasmon resonance (SPR) is one of the primary biophysical methods for the screening ...
Molecular interactions between proteins or between proteins and small molecules are pivotal events f...