Associations between activity and participation in adults with multiple sclerosis.

• Among people with MS, walking ability in a clinical setting is associated with walking ability in a person’s daily environment and walking performance in daily life • Only walking ability in a clinical setting is associated with participation • Our findings suggest that an increase of 61 m in 6MWT distance and a decrease of approximately 9 points on the MSWS-12 (score 12-60) is associated with clinically meaningful increase in daily step-count • The strength of the association between activity and participation is too weak for measures of activity to be considered surrogate indicators of participation.IDEA award from the Brunel University London Research Catalyst Fund and a research grant from the Association of Chartered Physiotherapists in Neurolog