Dramatic changes in glycan biosynthesis during oncogenic transformation result in the emergence of marker glycans on the cell surface. We analysed the N- linked glycans of L1CAM from different stages of melanoma progression, using high-performance liquid chromatography combined with exoglycosidase sequencing, matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry, and lectin probes. L1CAM oligosaccharides are heavily sialylated, mainly digalactosylated, biantennary complex-type structures with galactose β1-4/3-linked to GlcNAc and with or without fucose α1-3/6-linked to GlcNAc. Hybrid, bisected hybrid, bisected triantennary and tetraantennary complex oligosaccharides, and β1-6-branched complex-type glycans with or with...
Aberrant expression of sialic acids or altered linkage types is closely associated with malignant ph...
BACKGROUND. Although aberrant glycosylation is recognized as a hallmark of cancer, glycosylation in ...
Glycosaminoglycans (GAGs) are anionic polysaccharides present on cells and in the extracellular matr...
Dramatic changes in glycan biosynthesis during oncogenic transformation result in the emergence of m...
Dramatic changes in glycan biosynthesis during oncogenic transformation result in the emergence of m...
It is well documented that glycan synthesis is altered in some pathological processes, including can...
AbstractGlycosylation of integrins has been implicated in the modulation of their function. Characte...
Thesis by publication.Bibliography: pages 217-228.Chapter 1. Introduction -- Chapter 2. Structural f...
Recently, we reported comparative analysis of glycoproteins which express cancer-specific <i>N</i>-g...
Malignant melanoma is the sixth most commonly diagnosed cancer in developed countries. Like in many ...
Although both uveal (UM) and cutaneous (CM) melanoma cells derive from the transformed melanocytes, ...
Malignant melanoma is a highly aggressive tumour with increasing incidence and poor prognosis in the...
The glycome of one of the largest and most exposed human organs, the skin, as well as glycan changes...
Generally, most of ovarian cancer cannot be detected until large scale and remote metastasis occurs,...
Generally, most of ovarian cancer cannot be detected until large scale and remote metastasis occurs,...
Aberrant expression of sialic acids or altered linkage types is closely associated with malignant ph...
BACKGROUND. Although aberrant glycosylation is recognized as a hallmark of cancer, glycosylation in ...
Glycosaminoglycans (GAGs) are anionic polysaccharides present on cells and in the extracellular matr...
Dramatic changes in glycan biosynthesis during oncogenic transformation result in the emergence of m...
Dramatic changes in glycan biosynthesis during oncogenic transformation result in the emergence of m...
It is well documented that glycan synthesis is altered in some pathological processes, including can...
AbstractGlycosylation of integrins has been implicated in the modulation of their function. Characte...
Thesis by publication.Bibliography: pages 217-228.Chapter 1. Introduction -- Chapter 2. Structural f...
Recently, we reported comparative analysis of glycoproteins which express cancer-specific <i>N</i>-g...
Malignant melanoma is the sixth most commonly diagnosed cancer in developed countries. Like in many ...
Although both uveal (UM) and cutaneous (CM) melanoma cells derive from the transformed melanocytes, ...
Malignant melanoma is a highly aggressive tumour with increasing incidence and poor prognosis in the...
The glycome of one of the largest and most exposed human organs, the skin, as well as glycan changes...
Generally, most of ovarian cancer cannot be detected until large scale and remote metastasis occurs,...
Generally, most of ovarian cancer cannot be detected until large scale and remote metastasis occurs,...
Aberrant expression of sialic acids or altered linkage types is closely associated with malignant ph...
BACKGROUND. Although aberrant glycosylation is recognized as a hallmark of cancer, glycosylation in ...
Glycosaminoglycans (GAGs) are anionic polysaccharides present on cells and in the extracellular matr...