Brucella abortus depends on pyruvate phosphate dikinase and malic enzyme but not on Fbp and GlpX fructose-1,6-bisphosphatases for full virulence in laboratory models

Póster presentado en el 2nd International Symposium on Metabolism and Bacterial Pathogenesis, celebrado en Osnabrück (Alemania), del 6 al 9 de abril de 2014.Brucellosis is a disease of terrestrial and marine mammals and an important zoonosis. The ability of brucellae to multiply intracellularly in a variety of cells is the cornerstone of the biology of this pathogen and requires both controlling the intracellular trafficking and using the nutrients available in the replicative niche. The main carbon substrates used intracellularly for biosynthesis and energy production by Brucella are not known, and a better understanding of the adaptation to host cell nutrient supply is required.This work was funded by grants from Friends of the University of Navarra, Gobierno de Navarra, Ministerio de Ciencia y Tecnología (Spain), Institute of Tropical Health (University of Navarra) and UNAmur (Belgium)Peer Reviewe