Raman, infrared, or raman-infrared analysis of peripheral blood plasma protein structure and its relation to cognitive development in alzheimer's disease

[EN] The present invention relates to a Raman spectroscopy method for determining protein structure associated with global cognitive deterioration in Alzheimer's disease from the Raman spectroscopic analysis of a human blood sample, preferably of a human blood plasma sample, comprising obtaining at least one spectral value of at least one of the Raman spectrum regions comprised between 1600-1700 cm-1, between 910-980 cm-1, between 730-760 cm-1 and/or between 390-450 cm-1, and where said spectral value allows obtaining an indication of the presence or absence of protein structure associated with a condition of Alzheimer's disease. The present invention also relates to a method for the infrared spectroscopic analysis of a blood sample, by means of additionally obtaining at least one spectral value of at least one of the infrared spectrum regions comprised between 1600 and 1700 cm-1, and/or between 1000 and 1150 cm-1 and/or between 1140 and 1190 cm-1 Optionally, the Raman spectroscopy method further comprises the infrared spectroscopic analysis of the same blood sample. The invention also relates to a diagnostic method for diagnosing Alzheimer's disease comprising measuring a Raman spectrum and/or an infrared spectrum of a plasma samplePeer reviewedConsejo Superior de Investigaciones Científicas, Fundación Investigación Biomédica Hospital Universitario 12 de Octubre, Instituto de Salud Carlos III, Fundación Cien, Universidad Complutense de MadridA1 Solicitud de patente con informe sobre el estado de la técnic