In the first part of the thesis, protein-ligand interactions were investigated using the chaperone LcrH, from Yersinia as target protein. The structure of a peptide encompassing the amphipathic domain (residue 278-300) of the protein YopD from Yersinia was determined by NMR in 40% TFE. The structure of YopD278-300 is a well defined α-helix with a β-turn at the C-terminus of the helix capping the structure. This turn is crucial for the structure as peptides lacking the residues involved in the turn are unstructured. NMR relaxation indicates that the peptide is not monomeric. This is supported by intermolecular NOEs found from residue Phe280 to Ile288 and Val292 indicative of a multimeric structure with the helical structures oriented in an a...
The work described in this thesis focused on the use of nuclear magnetic resonance spectroscopy (NMR...
Paramagnetic nuclear paramagnetic resonance (NMR) spectroscopy and Double Electron-Electron Resonanc...
Abstract This paper describes efforts of the structural genomics project in the nuclear magnetic res...
In the first part of the thesis, protein-ligand interactions were investigated using the chaperone L...
In the last decades NMR spectroscopy has become an invaluable tool both in academic research and in ...
Proteins are important building blocks of all living organisms. They are composed of a defined seque...
NMR spectroscopy in many of the more recent applications can give relevant information in the study ...
This doctoral thesis deals with the structural and dynamical NMR characterization of biomolecules, c...
International audience2-D and 3-D NMR techniques were used to investigate the conformations in solut...
Experimentally derived biomolecular structures were determined by Nuclear Magnetic Resonance (NMR). ...
NMR spectroscopy is a universal technique for studying protein structure, function, dynamics, as wel...
NMR spectroscopy is a universal technique for studying protein structure, function, dynamics, as wel...
Proteins are the molecular machines of a cell and are involved in virtual all cellular processes. To...
Nuclear magnetic resonance (NMR) spectroscopy is a powerful method of determining three-dimensional ...
In the absence of specific interactions, the relative attenuation of protein NMR signals due to adde...
The work described in this thesis focused on the use of nuclear magnetic resonance spectroscopy (NMR...
Paramagnetic nuclear paramagnetic resonance (NMR) spectroscopy and Double Electron-Electron Resonanc...
Abstract This paper describes efforts of the structural genomics project in the nuclear magnetic res...
In the first part of the thesis, protein-ligand interactions were investigated using the chaperone L...
In the last decades NMR spectroscopy has become an invaluable tool both in academic research and in ...
Proteins are important building blocks of all living organisms. They are composed of a defined seque...
NMR spectroscopy in many of the more recent applications can give relevant information in the study ...
This doctoral thesis deals with the structural and dynamical NMR characterization of biomolecules, c...
International audience2-D and 3-D NMR techniques were used to investigate the conformations in solut...
Experimentally derived biomolecular structures were determined by Nuclear Magnetic Resonance (NMR). ...
NMR spectroscopy is a universal technique for studying protein structure, function, dynamics, as wel...
NMR spectroscopy is a universal technique for studying protein structure, function, dynamics, as wel...
Proteins are the molecular machines of a cell and are involved in virtual all cellular processes. To...
Nuclear magnetic resonance (NMR) spectroscopy is a powerful method of determining three-dimensional ...
In the absence of specific interactions, the relative attenuation of protein NMR signals due to adde...
The work described in this thesis focused on the use of nuclear magnetic resonance spectroscopy (NMR...
Paramagnetic nuclear paramagnetic resonance (NMR) spectroscopy and Double Electron-Electron Resonanc...
Abstract This paper describes efforts of the structural genomics project in the nuclear magnetic res...