Discontinuation of initial antiretroviral therapy in clinical practice: Moving toward individualized therapy
- Di Biagio A.
- Cozzi-Lepri A.
- Prinapori R.
- Angarano G.
- Gori A.
- Quirino T.
- De Luca A.
- Costantini A.
- Mussini C.
- Rizzardini G.
- Castagna A.
- Antinori A.
- Monforte A. D.
- Moroni M.
- Andreoni M.
- D'Arminio Monforte A.
- Castelli F.
- Cauda R.
- Di Perri G.
- Galli M.
- Iardino R.
- Ippolito G.
- Lazzarin A.
- Perno C. F.
- Von Schloesser F.
- Viale P.
- Ceccherini-Silberstein F.
- Girardi E.
- Lo Caputo S.
- Puoti M.
- Ammassari A.
- Balotta C.
- Bandera A.
- Bonfanti P.
- Bonora S.
- Borderi M.
- Calcagno A.
- Calza L.
- Capobianchi M. R.
- Cingolani A.
- Cinque P.
- Caputo N.
- Gianotti N.
- Guaraldi G.
- Lapadula G.
- Lichtner M.
- Madeddu G.
- Maggiolo F.
- Marchetti G.
- Marcotullio S.
- Monno L.
- Quiros Roldan E.
- Rossotti R.
- Rusconi S.
- Santoro M.
- Saracino A.
- Zaccarelli M.
- Fanti I.
- Galli L.
- Lorenzini P.
- Rodano A.
- Shanyinde M.
- Tavelli A.
- Giacometti A.
- Mazzoccato S.
- Santoro C.
- Suardi C.
- Vanino E.
- Verucchi G.
- Minardi C.
- Abeli C.
- Manconi P. E.
- Piano P.
- Vecchiet J.
- Falasca K.
- Sighinolfi L.
- Segala D.
- Mazzotta F.
- Alessandrini A.
- Piscopo R.
- Mazzarello G.
- Mastroianni C.
- Belvisi V.
- Caramma I.
- Chiodera A.
- Castelli A. P.
- Ridolfo A. L.
- Piolini R.
- Salpietro S.
- Carenzi L.
- Moioli M. C.
- Tincati C.
- Puzzolante C.
- Abrescia N.
- Chirianni A.
- Borgia G.
- Guida M. G.
- Gargiulo M.
- Gentile I.
- Orlando R.
- Baldelli F.
- Francisci D.
- Parruti G.
- Ursini T.
- Magnani G.
- Ursitti M. A.
- Vullo V.
- D'Avino A.
- Gallo L.
- Nicastri E.
- Acinapura R.
- Capozzi M.
- Libertone R.
- Tebano G.
- Viviani F.
- Sasset L.
- Mura M. S.
- Caramello P.
- Orofino G. C.
- Rossetti B.
- Sciandra M.
- Bassetti M.
- Londero A.
- Pellizzer G.
- Manfrin V.
DOIAbstract
Background: Study aim was to estimate the rate and identify predictors of discontinuation of first combination antiretroviral therapy (cART) in recent years. Methods: Patients who initiated first cART between January 2008 and October 2014 were included. Discontinuation was defined as stop of at least 1 drug of the regimen, regardless of the reason. All causes of discontinuation were evaluated and 3 main endpoints were considered: toxicity, intolerance, and simplification. Predictors of discontinuation were examined separately for all 3 endpoints. Kaplan-Meier analysis was used for the outcome discontinuation of ≥1 drug regardless of the reason. Cox regression analysis was used to identify factors associated with treatment discontinuation be...
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