Numerical strategies for optimal experimental design for parameter identification of non-linear dynamic (Bio-)chemical processes

6 páginas, 2 figurasThe problem of optimal experimental design (OED) for parameter estimation of non-linear dynamic systems is considered. It is shown how this problem can be formulated as a dynamic optimization (optimal control) problem where the performance index is usually a scalar function of the Fisher information matrix. Numerical solutions can be obtained using direct methods, which transform the original problem into a nonlinear programming (NLP) problem via discretizations. However, due to the frequent non-smoothness of the cost functions, the use of gradient-based methods to solve this NLP might lead to local solutions. Stochastic methods of global optimization are suggested as robust alternatives. A case study considering the OED for parameter estimation in a fed-batch bioreactor is used to illustrate the performance and advantages of two selected stochastic algorithms.Peer reviewe