The Negr1 gene has been significantly associated with major depression in genetic studies. Negr1 encodes for a cell adhesion molecule cleaved by the protease Adam10, thus activating Fgfr2 and promoting neuronal spine plasticity. We investigated whether antidepressants modulate the expression of genes belonging to Negr1-Fgfr2 pathway in Flinders sensitive line (FSL) rats, in a corticosterone-treated mouse model of depression, and in mouse primary neurons. Negr1 and Adam10 were the genes mostly affected by antidepressant treatment, and in opposite directions. Negr1 was down-regulated by escitalopram in the hypothalamus of FSL rats, by fluoxetine in the hippocampal dentate gyrus of corticosterone-treated mice, and by nortriptyline in hippocamp...
Background: The Flinders model is a validated genetic rat model of depression that exhibits a number...
The Flinders model is a validated genetic rat model of depression that exhibits a number of behaviou...
During the last few years several studies have highlighted the possibility that major depression can...
The Negr1 gene has been significantly associated with major depression in genetic studies. Negr1 enc...
In GWAS studies, the neural adhesion molecule encoding the neuronal growth regulator 1 (NEGR1) gene ...
RATIONALE: Monoaminergic imbalances play a role in the pathogenesis of depression and most common an...
Background: Psychological stress, particularly in chronic form, can lead to mood and cognitive dysfu...
Major depression is a highly prevalent, multidimensional disorder. Although several classes of antid...
Major depression is a highly prevalent, multidimensional disorder. Although several classes of antid...
The main goal of this study was to analyse genetic factors and pathway involved in depressive disord...
Several different interventions improve depressed mood, including medication and environmental facto...
<div><p>Several different interventions improve depressed mood, including medication and environment...
Previous research has shown that fibroblast growth factor 2 protein (FGF2) can act as an anxiolytic ...
of the general population, its pathogenesis is still essentially unknown. Recent studies highlighted...
A major hypothesis of depression postulates that a dysregulation of the neurotrophin systems is dire...
Background: The Flinders model is a validated genetic rat model of depression that exhibits a number...
The Flinders model is a validated genetic rat model of depression that exhibits a number of behaviou...
During the last few years several studies have highlighted the possibility that major depression can...
The Negr1 gene has been significantly associated with major depression in genetic studies. Negr1 enc...
In GWAS studies, the neural adhesion molecule encoding the neuronal growth regulator 1 (NEGR1) gene ...
RATIONALE: Monoaminergic imbalances play a role in the pathogenesis of depression and most common an...
Background: Psychological stress, particularly in chronic form, can lead to mood and cognitive dysfu...
Major depression is a highly prevalent, multidimensional disorder. Although several classes of antid...
Major depression is a highly prevalent, multidimensional disorder. Although several classes of antid...
The main goal of this study was to analyse genetic factors and pathway involved in depressive disord...
Several different interventions improve depressed mood, including medication and environmental facto...
<div><p>Several different interventions improve depressed mood, including medication and environment...
Previous research has shown that fibroblast growth factor 2 protein (FGF2) can act as an anxiolytic ...
of the general population, its pathogenesis is still essentially unknown. Recent studies highlighted...
A major hypothesis of depression postulates that a dysregulation of the neurotrophin systems is dire...
Background: The Flinders model is a validated genetic rat model of depression that exhibits a number...
The Flinders model is a validated genetic rat model of depression that exhibits a number of behaviou...
During the last few years several studies have highlighted the possibility that major depression can...